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Major function of the immune system Recognize between self and non-self
Guard against a broad range of pathogens and their effectiveness does not depend on prior exposure. Includes 1st line of defense(external surface membranes) and 2nd line of defense (inflammation, complement, cells, etc). Non-specific Resistance
This is the 3rd line of defense. Two types: Humoral & Cell Mediated Specific Immunity
Responsibility of B cells; produce antibodies that bind to antigens and tag for destruction Humoral Immunity
Responsibility of T cells; directly attach and destroy foreign cells Cell-mediated Immunity
Molecule that triggers an immune response Antigen
MCH is a ___ antigen Self antigen
Proteins which are found on the surface of cells and look like hotdog buns MCH
Found on all nucleated cells, produced by cell and transported to plasma membrane. Picks up peptides along the way. If peptides are self, immune system leaves it alone. If non self, triggers immune response. MCH-1
Found only on APC's to display only foreign antigens MCH-2
Bacteria, viruses, etc. that can mobilize the immune system and provoke a response. Non Self Antigen
Certain regions of an antigen molecule that stimule an immune response. One antigen have several different types of these. Epitopes
Ability to stimulate proliferation of specific lymphocytes and antibodies. Immunogenicty
Ability to react with products of immunogenicty (; lymphocytes and antibodies) Reactivity
Body makes own antibodies or T cells against pathogen Active Immunity
Body acquires antibodies from another person or animal that has developed its own immunity to the pathogen (borrowed) Passive Immunity
Body makes it own immunity Naturally Acquired
Induced artificially through vaccinations or immune serums Artificially Acquired
Reaction to vascular tissue to injury Inflammation
Proteins that circulate in the blood in inactive form and are activated in the presence of pathogens Complement
Antiviral proteins that alert neighboring cells and protect them from being infected Interferon
This cell kills bacteria in the connective tissue by phagocytosis and respiratory burst Neutrophils
This cell stand guard against parasites, allergens and other pathogens Eosinophils
Any cell of the body, other than a leukocyte, that is specialized for phagocytosis Macrophage
This cell can kill cancer cells and virus-infected cells. Does not depend on recognition or specific antigen but detect lack of self cell receptors Do not exhibit memory repsonse and are non-phagocytic Secrete inflammatory chemicals and perforin Natural Killer cells
Created by: 1123200155