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Wound Healing
WVSOM skin System 2012- adelman Wound healing
| Question | Answer |
|---|---|
| What are the phases of wound healing? | Inflammatory phase, migratory phase, proliferative phase, late phase scare remodeling |
| Name the portions of the inflammatory phase? | Hemostasis, vasodilation, phagocytosis |
| what occurs during hemostasis? | Vasoconstriction, platelet aggregation, release of cytokines, release of factor XII, |
| What occurs during vasodilation? | increased permeability for plasma proteins, RBC's, WBC's |
| how long does vasodilation last? | 5-7 days |
| What cells are involved with phagocytosis? | Macrophages and Neutrophils, PMN leukocytes, Monocyte |
| What can monocytes transition to? | macrophages |
| How long does the migratory phase last? | lasts 2days- 3 weeks |
| What is the priniciple action of the migratory phase? | Angiogenesis, epitheialization |
| define the epithelial response | Marginal basal cells undergo increased mitosis, daughter cells flatten to fill void |
| when does the proliferative phase begin? | 5 days after wound occurs |
| define fibroplasia | undifferentiated, extravascular mesenchymal cells transform to fibroblasts stimulated by injury |
| When does fibroplasia begin? | 5-7 post wound |
| What is the major collagen component of skin tissue | Type I |
| What is the second most common collagen component of skin tissue? | Type III |
| what makes collagen? what does it require? | Fibroblast; o2, ascorbic acid (vit C)and ferrous iron |
| how does collagen contract? | Myofibroblasts |
| what structural component is important for scar formation? | Cross-linkage to increase strength |
| Nutrition is important to wound healing. What occurs in the malnourished? | visceral and cuntaneous wound healing is stalled only in SEVERELY malnourished |
| what would an asorbic acid deficiency cause? | lack of hydroxylation of proline and lysine in collagen synthesis |
| what would a zinc deficency cause? | decreased cellular proliferation and granulation. |
| what would a zinc overdose cause? | inhibition of macrophage migration and phagocytosis |
| what affect does anemia and hypoxia have on wound healing? | HYPOXIA: inability to form collagen (hydroxylation of proline and lysine) ANEMIA: must be severe enough to limit circulating blood volume. |
| what is the effect of steroids on wound healing? | Adrenocortical steroids inhibit all aspects of healing. |
| when would you use steroids therapeutically? | KELOIDS |
| What can exaccerbate Keloid formation? | Vitamin A |
Created by:
Bwest8
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