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Skin Immuno

WVSOM Skin System 2012- Jackson Immunology

What is the role of Langerhan's cells in the skin system? They are APCs found in the epidermis which utilize MHC I and MHC II to activate T cells.
What is the role of keratinocytes in the skin system? They are MHC I predominantly and activate T cells.
What are the associated immunological proteins with langerhans cells? MHC class I and II, CD40,CAM,B7
What are the immuno proteins associated with Keratinocytes? MHC I and II, CAM, Prostaglandins, IL-1,6,8 and TNFa
What is allergic contact dermatitis? contact dermatitis is an inflammatory skin condition.
what is the biochemical/immunologic cause of allergic contact dermatitis? the antigen binds the langerhans cell which then presents to a T cell. The T cell then causes inflammation.
what are the three immunobullous diseases? Bullous Pemphigoid, Pemphigus,Dermatitis herpetiformis
What immunoglobulin is associated with Bullous Pempphigoid? IgG; subepidermal in location. Antibody against keratinocyte antigens.
how do you treat bullous pemphigoid? corticosteroids
what is the histological appearance of a skin sample with bullous pemphigoid? Total seperation of epidermis from the dermis.
what is pemphigus? Widespread blistering of skin and mucous membranes that involved autoantibodies against keratinocyte antigens.
what is the treatment for pemphigus? corticosteroids or azathiprine
what is intraepidermal acantholysis? seperation of the dermis and epidermis
what is dermatitis herpetiformis? associated with CELIAC DISEASE; pruritic vesicles that may appear on elbows, knees, back, neck or buttocks.
What is the histological marker in dermatitis herpetiformis? IgA deposits at dermal- epidermal junction
What is the definition of Psoriasis? sharply demarcated with clear borders, silvery scales, positive auspitz sign.
what is auspitz sign? Puncuate bleeding when scales are ripped off
what is Koebner phenomenon? linear presentation of rash
what is the pathogenesis of Psoriasis? T cell mediated process that causes an increased rate of proliferation and shedding of keratinocytes
What do you use to treat Psoriasis? UV light, PUVA, Steroids, retinoids, methotrexate
what are the biologic targets of therapies for Psoriasis? TNFa, TH17
Created by: Bwest8