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BIO202 - CH16 - PIP-Ca 2nd Messenger Mech - Marieb/Hoehn - RioSalado - AZ

In PIP, intracellular __ act as final mediator. Calcium ions
In PIP mechanism, activated G protein binds to & activates __. phospholipase C (effector enzyme)
Phospholipase C splits a plasma-membrane phospholipid __ into __ & __. PIP2 (phosphatidyl inositol biphosphate) into DAG & IP3
DAG activates __. Protein kinase C
IP3 triggers release of __ from ER. Ca2+
Liberated Ca2+ at end of PIP mechanism, takes on a 2nd messenger role by? Altering enzymes & Ca channels, or by binding to calmodulin.
Once Ca2+ binds to calmodulin, what happens? Enzymes are activated that amplify the cellular response.
Binding of thyroid-stimulating hormone promotes synthesis of? thyroxine
Binding of growth hormone (GH) in bone & muscle cells activates? anabolic reaction in which amino acids build into tissue proteins.
The insulin receptor is activated by __ when insulin binds. autophosphorylation (by its own tyrosines).
Created by: Ladystorm