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WBC's
Clin Path
| Question | Answer |
|---|---|
| Leukocytes: | White cell: WBC's |
| Normal WBC range in dogs | 6,000-17,000 |
| Normal WBC range in cats | 5,500-19,500 |
| Agranulocytes: | Lymphocytes and Monocytes |
| Granulocytes: | Basophil, eosinaphil, neutrophil |
| Production of Granulocytes: | Granulopoeisis |
| A wbc with a Pleomorphic nucleus | monocyte |
| mononuclear WBC: | Lymphocyte |
| 3 WBC's with poylmorphonuclear: | *neutrophil 3-5 lobes *eosinaphil 2-3 lobes, * basophil 2 lobes |
| Def: pleomorphic | varying shape; not segmented |
| Def: Polymorphonuclear | segmented |
| Which WBC is known as PMN? | Neutrophil |
| Which WBC is the first line defender? | Neutrophil |
| Which WBC is increased during allergic reaction? | Eosinaphil |
| What is the least commonly seen WBC? | Basophil |
| Which is largest cell in peripheral blood? | Monocyte |
| 3 types of lymphocytes: | *T lymphocytes *B-lymphocytes *natural killer cells |
| 2 chemicals that stimulate production of WBC's: | Interleukins and Interferons |
| Granulocyte in order of maturation: | *PPSC *Myeloid stem cell *Myeloblast *Promyelocyte *myelocyte *metamyelocyte *band cell *segmented granulocytes |
| Nutrophil granules are comprised of____ | Lysosomes |
| Eosinaphil granules are comprised of____ | antiihystamines |
| Basophil granules are comprised of____ and ____ | Histamine and heparin |
| Granules are produced by? | Golgi apparatus |
| What cell indicates a increased demand beyond bone marrow production? | Band cell |
| A neutrophil with more than 5 lobes is called a ______ | Hypersegmented/ senescence |
| a cell with 3-5 lobes is a ____ | Neutrophil |
| a cell with 2-3 lobes is a ____ | Eosinaphil |
| a cell with 2 lobes | Basophil |
| Predominant WBC of k-9, fel, horses & humanes? | Neutrophil |
| Predominant WBC of cattle, sheep & gaots? | Lymphocyte |
| The term for engulfing: | Phagocytosis |
| The process of of being attracted to a sight of infection by inflammatory chemicals: | Attraction |
| Plasma protein that coat microorganisms: | opsonins |
| name of pool which blood is sampled: | CNP: Circulating neutrophil pool |
| name of the storage pool where neutrophils line the cell walls: | MNP: Marginal neutrophil pool |
| Relative value calculation: | percentage of each cell type during the differential count is multiplied by the total WBC count |
| The numbers obtained during diff count are___ and have no significant finding. | Absolute |
| What is the primary role of Lymphocytes? | Defense |
| What is the only WBC that recirculates? | Lymphocytes |
| Nucleus become very dense and breaks apart in the tissue(cell death): | Pyknosis |
| What granulocytes will u see on a blood smear? | *myelocytes *metamyelocyte *band cell *segmented granulocytes |
| what cell has a storage supply in the bone marrow and for how long? | Segmented neutrophils *5 day supply |
| at what stage do granules form in granulocytes? | Promyelocyte |
| Primary granules are _____ and secondary granules are_____ | *Prim: Non specific *2nd Specific |
| Neutrophils are ___ microns in diameter | 10-12 |
| It takes how long to produce a mature neutrophil? can it be shortened? | *3-6 days *yes, causes toxic neutrophils(most significant in dogs) |
| How long do Neutrophils circulate in the blood? | 5-10 hours |
| How often are neutrophils replaced? | q 2 1/2 days |
| Monocytes convert to macrophage in ___ hrs | 72 |
| movement from out of the vessels into the tissue: | *Diapedesis |
| The only time hypersegmented neutrophils will be present in a blood sample: | *Old blood sample *Steroid therapy |
| ____ close finistrations inhibits Diapedesis | Steroids |
| Types of steroids: | Endogenous: Produce by body Exdogenous: administered |
| the highest # of neutrophils will be found in the : | Lungs, resp tract and GI tract |
| What is chemostaxis? | Chemical movement |
| Pseudo vacule: | Phagosome |
| Fussion: | Lysosomes line up on edge of vacule , fuse with membrane and secrete contents into vacules |
| Digestion: | A respiratory burst |
| Normal range for segmented neutrophils: | k-9: 3,000-11,400 Fel: 2,500-12,500 |
| Normal range for band neutrophils: | 0-300 both k-9/fel |
| Neutrophil counts can ___ and ____ WBC counts | increase and decrease |
| Normal range of circulating/marginal neutrophil pool: | K9 *CNP/MNP50 / 50 Fel:CNP- MNP30 / 70 |
| True or False: Neutrophils can pass freely from CNP to MNP | True |
| neutrophils move from MNP to CNP due to vasodialation: | Demargination |
| Bone marrow pool is a storage pool for what type of ____ neutrophils? | *segmented *band *metamylocyte *non dividing |
| Mitotic pools/proliferative pool is storage for what 3 _____ dividing neutrophils? | *myeloblast *promyelocyte *myelocytes |
| Left shift-regenerative: | more segmented neutrophils than band neutrophils |
| Left shift_degenerative: | More band neutrophils than segmented neutrophils (bone marrow unable to keep up with demand) |
| Increase above normal WBC count : | Neutrophilia or leukocytosis |
| bodies natural response to trauma: | Inflammation |
| ___ leukogram is the res ult of steriods: | Stress leukogram |
| Extreme neutrophilia ___ml | 50,000 ml |
| Abnormal proliferation of 1 or more types of WBC: | Leukemia |
| ____ is the decrease in neutrophils which leads to _____ | *neutropenia *leukocytopenia |
| Severe or sudden drop in neutrophils: | Cyclic neutropenia (collies :idiopathic) |
| Bacteria + toxins: | Endotoxemia |
| Normal eosinaphil range: | K-9:100-750ml Fel:0-750ml |
| Eosinaphils make up __% of total WBC count | 0.5 |
| How long does it take to produce a mature Eosinphil? | 2-6 days |
| Eosinaphils circulate in the blood for __ and live in the tissue for ___ | *5-18 hrs *1wk |
| what shape are eosinaphils in k-9 and fel? | k-9:Round Fel:rod shaped |
| what is are Eosinphils primary responsibly? | Anti inflammatory response |
| Eosinaphils will increase in circulation with ___ infestation? | parasite |
| What antibacterial component do eosinaphils have? | Myeloperoxidase |
| What condition involving eosinaphils is most common in cats? | Eosinaphilic leukemia |
| New growth: | Neoplasia |
| What is the rarest WBC seen? | Basophil |
| Basophils circulate in the blood for ___and live in the tissue for ___ | *6hrs *2wks |
| Tumor that Originates in tissue and stays in tissue that are not H20 soluble: | mast cell |
| Mast cell tumors are most prevalent in what areas of the body and what ssp? | *lung, skin, Gi tract, uterus *canine |
| Physiologic leukogram are caused by: | Epinephrine release:TWBC increase |
| Inflammatory leukogram caused by: | Inflammation, infectious or non infectious: TWBC increase and decrease |
Created by:
brit_2112
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