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Turnicky 06 Hemostas

Turnicky: Hemostasis

Formation of a platelet plug Primary hemostasis
Formation of fibrin through the coagulation cascade Secondary hemostasis
Formation of plasmin for breakdown of the clot Tertiary hemostasis
Vitamin K dependent factors II VII IX X
Needed for post-ribosomal attachment of COOH to glutamic acid Vitamin K
COOH provides... Ca receptor essential for binding the factor to phospholipid
Monitor in coumadin therapy PT time
Monitor in heparin therapy aPTT time
Intrinsic Pathway time aPTT
Extrinsic pathway time PT
Common pathway time Thrombin time
Contains mediators of platelet function, ADP, ATP, Ca, and serotonin Platelet dense bodies
Contains hemostatic proteins: fib, FV, vWF, PAI-I and plasminogen Platelet alpha granules
Most numerous platelet granules Alpha granulues
Platelet adhesion Attachment of platelets to something besides other platelets
Platelet aggregation Attachment of platelets to one another
Platelet secretion Discharge of granular contents into the surrounding area
Created by: bcriss