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Turnicky 04 Acc. RC

Turinicky: Accelerated Red Cell Turnover

>4% reticulocytes on peripheral blood smear Accelerated Red Cell Turnover
Microspherocytes Characteristic of Hemolytic anemia
Antibody formation to foreign antigens Alloimmune Reaction
2 Alloimmune situations Hemolytic transfusion reaction Hemolytic disease of the new born
3 autoimmune hemolytic anemia situations Warm Cold Paroxysmal cold hemoglobinemia
Heinz bodies G6PD
G6PD is asymptomatic until... Illness or exposure to certain drugs
Most common enzyme disorder G6PD deficiency
Second most common enzyme deficiency Pyruvate kinase deficiency
Most common enzyme deficiency in the Embden-Meyerhor pathway Pyruvate kinase deficiency
Hyperchromic anemia Hereditary Spherocytosis
Schistocyte Microangiopathic anemia
Childhood tetrad of Hemolytic Uremic Syndrome Hemolytic anemia w/schistocytes Acute renal failure Thrombocytopenia CNS symptoms (seizures)
Pentad of clinical findings for TTP *Fever *Renal dysfunction Microangiopathic HA Thrombocytopenia CNS Symptoms
Disorder of vWF TTP
vWF cleaving protease or... ADAMTS-13
Free Hgb circulating in the plasma Hemoglobinemia
Free Hgb filtered by the kidney Hemoglobinurea
Created by: bcriss