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Renal 01 RBF and GFR
Hamra: Renal Blood Flow and GFR
| Question | Answer |
|---|---|
| What part of the nephron allows for water resorption while blocking sodium. | The thin descending limb |
| What part of the nephron allows for sodium resorption while blocking water. | The thick ascending limb |
| Name the 3 major parts of the Juxtaglomerular apparatus. | 1. Renin-producing granular cells 2. Macula densa 3. Extraglomerular mesangial cells |
| Do the extraglomerular mesangial cells effect eh afferent or efferent arteriole? | As the cells contract they change the tone of the afferent arterioles. |
| What are the 4 possibilities a fluid has traveling in the nephron? | 1. Filtered 2. Reabsorbed 3. Secreted 4. Excreted |
| What id glomerular filtration rate (GFR)? | Volume/Time Normal = 180 L/day or 125 mL/min |
| What determines the rate of filtration? | Rate = Kf X NFP Kf = hydraulic permeability X surface area |
| What is included in the net filtration pressure (NFP)? | NFP = Pgc - Pcb - πgc So GFR = Kf (Pgc - Pbc - πgc) |
| How will increasing Kf effect GFR? | Increases GFR |
| How will increasing Pgc effect GFR? | Increases GFR |
| How will increasing Pbc effect GFR? | Decreases GFR |
| How will increasing πbc effect GFR? | Decreases GFR |
| Increase in afferent arteriolar resistance will effect Pgc, GFR, and RBF in what ways? | Decreases Pgc Decreases GFR Decreases RBF |
| Increase in efferent arteriolar resistance will effect Pgc, GFR, and RBF in what ways? | Increase Pgc increases GFR Decrease RCF |
| What about equal increase in afferent and effecent resistance | Can cause decrease in RBF while the Pgc stays about the same |
| Explain filtration factor a little bit. | FF = GFR/RPF FF is greater at low plasma flow |
| What will SNS stimulation and angiotension II do in regards to the kidney? | It will increase afferent and efferent resistances and decrease RBF. |
| Where does angiotension II work most? | Efferent arterioles |
| What effect will an ACE/ARB have on GFR? | CAE/ARB will cause vasodilation of the efferent arterioles thus decreasing GFR |
| How are changes in GFR sensed? | As increases or decreases in NaCl sensed by the Macula Dense |
| Paracrines from the Macula Dense work where? | In the afferent arteriole or vasoconstrict/dilate |
| What is the over all effect of the SNS and RAAS system in regards to GFR? | decrease in RPF with only a little or no change in GFR |
| How does ADH (vasopressin) work? | Vasoconstricts but normally RBF and GFR remain constant |
| What about ANP? | Afferent dilation, causing increases in both GFR and RBF. Also inhibits the secretion of Renin |
| What is the role of prostaglandins? | Generally protective against excessive vasoconstriction like that seen with SNS and ANG II |
Created by:
bcriss
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