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Renal 01 RBF and GFR

Hamra: Renal Blood Flow and GFR

QuestionAnswer
What part of the nephron allows for water resorption while blocking sodium. The thin descending limb
What part of the nephron allows for sodium resorption while blocking water. The thick ascending limb
Name the 3 major parts of the Juxtaglomerular apparatus. 1. Renin-producing granular cells 2. Macula densa 3. Extraglomerular mesangial cells
Do the extraglomerular mesangial cells effect eh afferent or efferent arteriole? As the cells contract they change the tone of the afferent arterioles.
What are the 4 possibilities a fluid has traveling in the nephron? 1. Filtered 2. Reabsorbed 3. Secreted 4. Excreted
What id glomerular filtration rate (GFR)? Volume/Time Normal = 180 L/day or 125 mL/min
What determines the rate of filtration? Rate = Kf X NFP Kf = hydraulic permeability X surface area
What is included in the net filtration pressure (NFP)? NFP = Pgc - Pcb - πgc So GFR = Kf (Pgc - Pbc - πgc)
How will increasing Kf effect GFR? Increases GFR
How will increasing Pgc effect GFR? Increases GFR
How will increasing Pbc effect GFR? Decreases GFR
How will increasing πbc effect GFR? Decreases GFR
Increase in afferent arteriolar resistance will effect Pgc, GFR, and RBF in what ways? Decreases Pgc Decreases GFR Decreases RBF
Increase in efferent arteriolar resistance will effect Pgc, GFR, and RBF in what ways? Increase Pgc increases GFR Decrease RCF
What about equal increase in afferent and effecent resistance Can cause decrease in RBF while the Pgc stays about the same
Explain filtration factor a little bit. FF = GFR/RPF FF is greater at low plasma flow
What will SNS stimulation and angiotension II do in regards to the kidney? It will increase afferent and efferent resistances and decrease RBF.
Where does angiotension II work most? Efferent arterioles
What effect will an ACE/ARB have on GFR? CAE/ARB will cause vasodilation of the efferent arterioles thus decreasing GFR
How are changes in GFR sensed? As increases or decreases in NaCl sensed by the Macula Dense
Paracrines from the Macula Dense work where? In the afferent arteriole or vasoconstrict/dilate
What is the over all effect of the SNS and RAAS system in regards to GFR? decrease in RPF with only a little or no change in GFR
How does ADH (vasopressin) work? Vasoconstricts but normally RBF and GFR remain constant
What about ANP? Afferent dilation, causing increases in both GFR and RBF. Also inhibits the secretion of Renin
What is the role of prostaglandins? Generally protective against excessive vasoconstriction like that seen with SNS and ANG II
Created by: bcriss
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