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lecture 9 dowell

vincristine's unique properties NON-emetogenic and NON-myelosuppressive
dexamethasone action directly lympholytic
time frame for rescue with leucovorin < 36 hrs
brain is a sanctuary site for mets many chemotherapy agents don't achieve adequate levels in the CNS
dose dense tx giving the same amt of drug but over a shorter period of time /// advantages: less time for tumor repopulation, disadvantages: much increased risk for toxicity
why leucovorin potentiates effect of 5-FU ternary complex of 5-FdUMP, thymidylate synthase and methylene tetrahydrofolate is needed to stop purine synthesis. with more folate in the cell, more enzyme can be inhibited by 5-FU
pt develops acute myocarditis, ventricular tachy and resultant sz after chemo, suspect which drug? doxorubicin (anthracyclines) has known unique cardiomyopathy side effect
secondary leukemia has been described after exposure to? alkylating agents, epipodophyllotoxins and anthracyclines
Created by: sirprakes