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clincorrelAntiCancer
lecture 9 dowell
Question | Answer |
---|---|
vincristine's unique properties | NON-emetogenic and NON-myelosuppressive |
dexamethasone action | directly lympholytic |
time frame for rescue with leucovorin | < 36 hrs |
brain is a sanctuary site for mets | many chemotherapy agents don't achieve adequate levels in the CNS |
dose dense tx | giving the same amt of drug but over a shorter period of time /// advantages: less time for tumor repopulation, disadvantages: much increased risk for toxicity |
why leucovorin potentiates effect of 5-FU | ternary complex of 5-FdUMP, thymidylate synthase and methylene tetrahydrofolate is needed to stop purine synthesis. with more folate in the cell, more enzyme can be inhibited by 5-FU |
pt develops acute myocarditis, ventricular tachy and resultant sz after chemo, suspect which drug? | doxorubicin (anthracyclines) has known unique cardiomyopathy side effect |
secondary leukemia has been described after exposure to? | alkylating agents, epipodophyllotoxins and anthracyclines |