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AED adverse effects

Antiepileptic drugs adverse effects

QuestionAnswer
Phenobarbital/Primidone acute Sedation, fatigue, ataxia, blurry vision
Phenobarbital/Primidone chronic Hiperactive (children), learning, depression
Phenobarbital/Primidone idiosyncratic Rash, connective tissue disorders, hepatoxicity
Phenytoin acute Somnolence, dizziness, ataxia, blurry vision, N
Phenytoin chronic Neuropathy, gum hyperplasia, hirsutism, low thyroid, osteoporosis
Phenytoin idiosyncratic SJS, lupuslike reactions, pseudolymphoma, hepatitis, blood dyscrasias
Ethosuximide acute Somnolence, NVdiarrhea, dizzines, anorexia, abdominal pain
Ethosuximide chronic Behavioral changes, irritability, nervousness, confusion, psychosis
Ethosuximide idiosyncratic SJS, lupuslike reaction, blood dyscrasias, hepatoxicity, generalized Sz increase
Carbamazepine acute Somnolence, fatigue, rash, diplopia, dizziness, ataxia, NV
Carbamazepine chronic Behavioral changes, low sodium, weight gain/edema
Carbamazepine idiosyncratic SJS, hepatoxicity, aplastic anemia/low white blood cell count
Valproic acid acute Abdominal pain, NVdiarrhea, hyperammonemia
Valproic acid chronic Tremor, alopecia, amenorrhea, weight gain
Valproic acid idiosyncratic Liver/pancreatic failure, low platelets, birth defects
Felbamate acute Headache, NV, rash
Felbamate chronic Anorexia, weight loss, insomnia
Felbamate idiosyncratic SJS, aplastic anemia, hepatic failure
Gabapentin/pregabalin acute Somnolence, fatigue, ataxia, dizziness, blurry vision
Gabapentin/pregabalin chronic Weight gain, pedal edema, behavior changes (children), CPK
Gabapentin/pregabalin idiosyncratic NONE
Lamotrigine acute Dizziness, diplopia, blurry vision, NV, ataxia
Lamotrigine chronic Headache, insomnia, incoordination, tic
Lamotrigine idiosyncratic SJS, TEN, DRESS, myoclonic Sz increase
Topiramate acute Somnolence, dizziness, fatigue, anorexia, N
Topiramate chronic Mental slowing, speech and memory disturbance, paresthesias, weight loss, renal stones
Topiramate idiosyncratic Hepatic failure, oligohidrosis, glaucoma
Tiagabine acute Headache, dizziness, fatigue, NV, abdominal pain
Tiagabine chronic Abnormal thinking, tremor, nervousness
Tiabagine idiosyncratic Nonconvulsive spike-wave stupor
Oxcarbazepine acute Somnolence, dizziness, fatigue, NV
Oxcarbazepine chronic Hyponatremia (elderly), insomnia, headache
Oxcarbazepine idiosyncratic SJS, TEN
Levetiracetam acute Somnolence, dizziness, fatigue, N
Levetiracetam chronic Irritability, anger, anxiety, depression
Levetiracetam idiosyncratic NONE
Zonisamide acute Somnolence, ataxia, NV, dizziness, fatigue
Zonisamide chronic Lost apetite, speech, paresthesias, weight loss, renal stones, apathy
Zonisamide idiosyncratic Rash, hypersensitivity reactions (sulfa)
Rufinamide acute Somnolence, NV, headache, dizziness, fatigue
Rufinamide chronic Incoordination, ataxia, shortened QT interval
Rufinamide idiosyncratic Rash, DRESS
Lacosamide acute Somnolence, dizziness, N, fatigue, diplopia
Lacosamide chronic Headache, tremor, ataxia, incoordination, depression
Lacosamide idiosyncratic NONE
Vigabatrin acute Somnolence, dizziness, fatigue, blurred vision, arthralgia
Vigabatrin chronic Weight gain, edema, neuropathy, depression
Vigabatrin idiosyncratic Permanent visual field loss, psychosis
Created by: 1042022037
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