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Integumentary System


Cells of epidermis -L- -keratinized stratified squamous epithelium -keratinocytes, melanocytes, Merkel cells, and Langerhans' cells
keratinocytes -K- epidermal cell that produces keratin, gives the epidermis its protective properties (waterproofing)
melanocytes -L- epithelial cells of epidermis that synthesize and secrete melanin, found in the deepest layer of epidermis
melanosomes membrane-bound granules where melanin is accumulates, protects keratinocyte nucleus from UV
Langerhans' cells -L- AKA dendritic cells, phagocytes that ingest foreign substances and help activate our immune system, migrate from bone marrow to epidermis
Merkel Cells -L- present at epidermal-dermal junction, associated with a dermal nerve endings. -acts as a sensory receptor for touch
Merkel disc functions as a sensory receptor for touch
Layers of Epidermis (Deept to Superficial) stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum
stratum basale structure -L- deepest layer of epidermis, has single row of cells, young keratinocytes,small number of melanocytes and merkel cells, occasionall merkel cells are present
stratum spinosum -L- 8-10 rows of keratinocytes that appear irregular in shape. langerhans' and melanosomes conneced by desmosomes
stratum granulosum -L- 3 to 5 layers flat keratinocytes with disintegrating organelles - keratohyalin granules and lamellated granules occure
keratohyaline granules found in stratum granulosum, helps to from keratin in the upper layers of epidermis
lamellated granules found in stratum granulosum, contains waterproofing glycolipid that is a major factor in slowing water loss across the epidermis
stratum lucidum -L- 2-3 rows of clear, flat, dead keratinocytes. Present in only thick skin
stratum corneum -L- outer most layer of epidermis, consist of 20 -30 dead keratinocytes filled with keratin and connected by glycolipids. - thickes layer of epidermis
stratum basale function -L- mitosis to replace cells lost superficially. - melanin production. - touch
stratum spinosum function -L- keratin production begins. - some mitosis begins
stratum corneum -L- waterproofing
Created by: karin.thompson