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Anatomy Unit 2
| Term | Definition |
|---|---|
| skin (cutaneous membrane) | largest organ of the body |
| epidermis and dermis | two main parts of the skin |
| epithelial tissue | tissue of epidermis |
| connective tissue | tissue of the dermis |
| subcutaneous layer | lies beneath the skin and is NOT part of the skin |
| hair, glands, nails | accessory structures of integumentary system |
| protection, prevent h2o loss/gain, metabolic regulation, absorption/secretion, immune functions | epidermis functions |
| temp regulation, secretion/absorption, sensory reception | dermis functions |
| epidermis | thin, superficial layer of skin, avascular, keratinized stratified squamous |
| keratinocytes | 90% of epidermis, produce keratin, lamellar granules contribute to water repellency |
| melanocytes | 8% of epidermis, produce melanin, projections between keratinocytes, melanin absorbs UV light/protect keratinocytes |
| intraeptdermal macrophages (Langhans cells) | Originate from red bone marrow and migrate to epidermis, immune response, destroy microbes |
| tactile epithelial cells (Merkel cells) | located in stratum basale, touch sensation, tactile disc |
| basale, spinosum, granulosum, lucidum, corneum | order of epidermal strata |
| stratum basale | deepest layer, active mitosis, tonofilaments, desmosomes and hemidesmosomes, melanocytes, Merkel cells |
| stratum spinosum | 8-10 layers; spiny, strong and flexible, keratin intermediate fibers, desmosomes, absorbs melanin, superficial cells flatten |
| stratum granulosum | transitional zone, about 3-5 layers, flat, dying cells, apoptosis, lamellar granules, water-repellant; keratohyalin contributes to keratin |
| stratum lucidum | only in thick skin like fingertips, palms, and soles; 4-6 layers of clear flat, dead keratinocytes filled with keratin |
| stratum corneum | outermost; about 25-30 layers in thin skin and 50+ in thick skin; dead keratinized water repellant cells; constantly shed |
| epidermal growth | newly formed cells in stratum basale pushed upward cells undergo keratinization/apoptosis as they move towards surface 4-6 weeks from basale to corneum EGF simulates growth of ep. cells/fibroblasts |
| EGF | Epidermal Growth Factor |
| Dermis | thickest layer and deep to the epidermis; made of dense irregular connective tissue w/ collagen and elastic fibers |
| accessory structures of dermis | glands, hair, nerves, blood vessels |
| papillary and reticular layer | regions of the dermis |
| papillary layer | superficial/thin; 20% of dermis; areolar CT |
| dermal papillae; capillary loops; meissner''s corpuscles; free nerve endings | how to recognize papillary layer |
| reticular layer | deep/thicker; dense irregular connective tissue; net-like arrangement |
| hair follicles, nerves, sebaceous glands, sudoriferous glands | how to recognize reticular layer |
| Meissner's corpuscles | associated with touch sensations |
| free nerve endings | associated with warmth, cool, pain, and itch |
| root plexus | sensitive to touch around hair follicles |
| tension lines | reflect direction of underlying collagen fibers |
| perpendicular | what incision creates more scarring? |
| parallel | what incision creates thinner, finer scars |
| found over most of the body except palms, soles, and a few small areas | where is hair found? |
| epidermis | where do hair and follicles develop from |
| hair | columns of dead, keratinized epidermal cells |
| shaft | visible part of hair |
| root | embedded in dermis |
| hair follicle | surrounds root |
| bulb | swollen portion surrounding root |
| hair matrix | innermost layer of follicle; site of growth |
| papilla | cluster of capillaries beneath the hair matrix |
| root plexus | sensitive to touch |
| arrestor pili | associated with goose bumps |
| 5 in | how much does hair grow per year |
| growth stage | matrix divides and pushes hair; 2-6 years |
| regression stage | matrix stops dividing; 2-3 weeks |
| resting stage | last stage; new growth cycle begins; 3 months |
| sebaceous gland function | lubricates hair/skin; secretion increases during adolescence |
| sebaceous gland location/product | connected to hair follicles; secrete sebum |
| sebaceous gland classification/mechanism | holocrine; simple branched acinar |
| ceruminous gland function | contributes to earwax; provides sticky barrier against foreign bodies |
| ceruminous gland location/product | external ear canal; modified sweat gland; secretes cerumen |
| ceruminous gland classification/mechanism | apocrine |
| eccrine sweat gland function | produces sweat/is involved in maintaining body-temp homeostasis |
| eccrine sweat gland location/product | most numerous in forehead, palms, soles, excretory portion in deep dermis |
| eccrine sweat gland classification/mechanism | merocrine; simple coiled tubular |
| apocrine sweat gland function | more viscous secretion w/ lipids/proteins; interacts w/ bacteria for body odor |
| apocrine sweat gland location/product | axilla, groin, areolae of breasts, bearded regions of males, duct opens into hair follicles |
| apocrine sweat gland classification/mechanism | merocrine mechanism; simple coiled tubular |
| nails | consist of epidermal cells converted to hard keratin |
| nail body | visible part of each nail |
| root | part in groove hidden by cuticle |
| lunula | moon-shaped white area near root |
| nail bed | layer of epithelium under nail body; contains abundant BV |
| eponychium | cuticle |
| mitosis of cells in stratum basale beneath lunula; 1 in/yr | how does growth occur in nails |
| restoration of normal/near normal function and structure | goal of wound healing of the skin |
| epidermal and deep wound | types of wound healing of skin |
| epidermal wound healing example | abrasions and minor burns |
| epidermal wound healing process | basal cell moves into wounded area and enlarges; migration continues until wound is resurfaced, contact inhibition stops migration; cells form new strata |
| EGF connection | Epidermal growth factor stimulates growth of epidermal cells and fibroblasts |
| Deep wound healing example | injury to dermis and subcutaneous layer |
| inflammatory, migratory, proliferative, maturation | deep wound healing phases |
| inflammatory phase | vascular/cellular response; blood clot forms; WBCs migrate to destroy invading microorganisms |
| Migratory phase | scab forms, epidermal cells migrate beneath scab to bridge wound; fibroblasts form scar tissue; granulation tissue forms |
| proliferative phase | extensive growth of epidermal cells; collagen deposited |
| maturation phase | scab sloughs off; epidermal cells are replaced toward original thickness; collagen fibers organize |