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2CK TumorMarkers

USMLE 2CK - Tumor Markers

QuestionAnswer
PSA Prostate-specific antigen. Used to screen for prostate carcinoma.
Prostatic acid phosphatase Prostate carcinoma.
CEA Carcinoembryonic antigen. Very nonspecific but produced by approx. 70% of colorectal and pancreatic cancers; also produced by gastric and breast carcinomas.
α-fetoprotein Normally made by fetus. Hepatocellular carcinomas. Nonseminomatous germ cell tumors of the testis (yolk sac tumor). Ovarian endodermal sinus tumors and embryonal carcinoma.
β-hCG Hydatidiform moles, choriocarcinomas, and gestational trophoblastic tumors. Ovarian germ cell tumor (embryonal carcinoma).
CA-125 Ovarian, malignant EPITHELIAL tumors.
S-100 Melanoma, neural tumors, astrocytomas.
Alkaline phosphatase Metastases to bone, obstructive biliary disease, Paget’s disease of bone.
Bombesin Neuroblastoma, lung and gastric cancer.
TRAP Tartrate-resistant acid phosphatase. Hairy cell leukemia––a B-cell neoplasm.
CA-19-9 Pancreatic adenocarcinoma.
LDH Dysgerminoma (germ cell) tumors of the ovary.
Inhibin Granulosa (stromal) cell tumor of the ovary.
Estrogen Granulosa (stromal) cell tumor of the ovary. Can cause endometrial hyperplasia → diffuse uterine enlargement.
Created by: megankirch
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