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Acute itis response

Acute inflammatory response

TermDefinition
Chronic granulomatous disease (CGD) X- linked recessive defect in NADPH oxidase. Phagocytes unable to produce reactive oxygen species. Myeloperoxidase activity (H O → HOCl) remains intact.
CGD patients are susceptible to recurrent infections from catalase positive organisms Staphylococcus, Listeria, Escherichia coli, Serratia, Pseudomonas Fungi --> Aspergillus, Candida
Why catalase positive organisms? (CGD) neutralize their own hydrogen peroxide.
What is responsible for transmigration? PECAM-1 (Platelet Endothelial Cell Adhesion Molecule) or CD31
What cause the activation of the endothelial cells? IL-1, IL-6 and TNF Therefore, activation of ICAM and VCAM.
What are the chemoattractants? (4) LTB4, C5a, microbe peptides, and IL-8
What happens to protein with chronic inflammation? 1. Increase IgG and Raised globulin peak, that is, polyclonal gammopathy. 2. Greater decrease of Albumin.
Deficiency of what causes LAD Type 1? Beta 2- Integrin (CD11, LFA-1 and CD18).
What is the result of LAD type 1? Increase serum neutrophil. No pus. Omphalitis
Which cytokines cause the slectins to express on the endothelium? Tumor Necrosis Factor and IL-1 This enable the expression of the selectin ligand on the leukocytes.
What enables the leukocytes to roll? Selectin on the damaged endotheilum. Selectin ligand on the leukocytes.
What helps the leukocytes to transmigrate? PECAM-1/CD31
Which cells first encounter pathogens? Tissue Macrophages/Activated Macrophages
Which leukocyte tends to migrate to the damaged epithelium? Neutrophils
Which cell carry away the microbial to the spleen and lymph nodes/ Dendritic Cell
Which cell can take on the role of macrophage and dendritic cells? Monocytes
Created by: Jameel D. Wilson
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