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Slide Notes Rez

Rezdiffra slide notes for presentation

QuestionAnswer
slide 7 again, the approved indication is in addition to diet and exercise.
slide 9 What this slide is saying is that there is hepatotoxicity observed dueing trial. Patients need to be monitored for s/s of a hepatotoxicity after initiating. If stopping did not return labs to normal, should consider autoimmune liver disease.
Slide 10 Rez through the stimulation of thyroid hormone receptor beta achieves the reduction of triglycerides in the liver. The fat content was observed by MRI-PDFF at week 16 and 52. It was also observed with Fibroscan cap score at week 52.
Slide 12 Actions of thyroid hormone outside of liver, such as heart and bones, are mediated through THR - Alpha receptor
Slide 14 biopsy happened at the start and at week 52.
Slide 16 NAS is a composite score of three histologic observations: steatosis, lobular inflammation and hepatocyte ballooning.
Created by: jcy2124
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