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Teratology

Psychiatric Meds

QuestionAnswer
Maternal prenatal stress/depression is associated with.. low infant birth weight and prematurity, also temperament and behavior
Women with schizophrenia or a major affective disorder have an increased risk for... fetal distress, abruptio placenta, IUGR, and babies with heart defects
When compaired to babies whose mothers were depressed but took no meds, babies exposed to SSRIs had... lower birth weight, gestational age, respiratory distress, jaundice and feeding problems
Antidepressants and pregnancy: SSRIs (and tricyclics) Low risk for malformations, risk for problems in newborn period
Antidepressants and pregnancy: Paxil small increase risk for heart defects (~1%), significant problems for newborn adaptation
Antidepressants and pregnancy: Effexor significant problems with newborn adaptation
Antidepressants and pregnancy is a... continued area of study, risk is unlikely to be large but unlikely to be zero
SSRIs and neonatal adaption: neonatal behaviorial syndrome CNS (Irritability and agitation), Motor (tremors, increased muscle tone), respiratory distress, GI difficulties, onset between birth and 3 weeks and typically lasts less than two weeks
Neonatal behaviorial syndrome most implicated with what 3 drugs Paxil, Prozac and Effexor
Medical management for Neonatal adaptation syndrome Supportive care in the NICU, toxicity versus withdrawal.. occasionally small doses of the maternal medication are administered
FDA says (with SSRIs) 3rd trimester exposure leads to... 20-30% risk for neonatal behavioral syndrome and 1% risk for PPHN
Lithium (~1%) risk for Ebstein's anomaly, fetal echocardiogram at 20 weeks is recommended. 3rd trimester has been associated with LOTS OF stuff...
Lithium in 3rd trimester... neonatal cyanosis, hypotonia, cardiac rhythm disturbances, diabetes insipidus and hypothyroidism
Antipsychotics: Haldol limb defects, extrapyramidal effects in third trimester
Antipsychotics: Risperdal Reassuring!!!!
Antipscyhotics: Zyprexa Reassuring. But maternal weight gain may lead to OB complications
Infants and breastfeeding: Long term effects of psychotropics on neurocognitive development are... largely unknown
Infants and breastfeeding: Potential acute efects of SSRIs on infants
Maternal prenatal stress/depression is associated with.. low infant birth weight and prematurity, also temperament and behavior
Women with schizophrenia or a major affective disorder have an increased risk for... fetal distress, abruptio placenta, IUGR, and babies with heart defects
When compaired to babies whose mothers were depressed but took no meds, babies exposed to SSRIs had... lower birth weight, gestational age, respiratory distress, jaundice and feeding problems
Antidepressants and pregnancy: SSRIs (and tricyclics) Low risk for malformations, risk for problems in newborn period
Antidepressants and pregnancy: Paxil small increase risk for heart defects (~1%), significant problems for newborn adaptation
Antidepressants and pregnancy: Effexor significant problems with newborn adaptation
Antidepressants and pregnancy is a... continued area of study, risk is unlikely to be large but unlikely to be zero
SSRIs and neonatal adaption: neonatal behaviorial syndrome CNS (Irritability and agitation), Motor (tremors, increased muscle tone), respiratory distress, GI difficulties, onset between birth and 3 weeks and typically lasts less than two weeks
Neonatal behaviorial syndrome most implicated with what 3 drugs Paxil, Prozac and Effexor
Medical management for Neonatal adaptation syndrome Supportive care in the NICU, toxicity versus withdrawal.. occasionally small doses of the maternal medication are administered
FDA says (with SSRIs) 3rd trimester exposure leads to... 20-30% risk for neonatal behavioral syndrome and 1% risk for PPHN
Lithium (~1%) risk for Ebstein's anomaly, fetal echocardiogram at 20 weeks is recommended. 3rd trimester has been associated with LOTS OF stuff...
Lithium in 3rd trimester... neonatal cyanosis, hypotonia, cardiac rhythm disturbances, diabetes insipidus and hypothyroidism
Antipsychotics: Haldol limb defects, extrapyramidal effects in third trimester
Antipsychotics: Risperdal Reassuring!!!!
Antipscyhotics: Zyprexa Reassuring. But maternal weight gain may lead to OB complications
Infants and breastfeeding: Long term effects of psychotropics on neurocognitive development are... largely unknown
Infants and breastfeeding: Potential acute efects of SSRIs on infants GI Disturbances (Prozac), irritability, somnolence
Potential long term effects of SSRIs while breastfeeding Neurobehavioral changes, decreased wt gain
Mood stabilizers American Academy of Pediatrics classifies lithium as not compatible with breastfeeding
Created by: KChatham
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