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Alzheimer’s Disease

Pathophysiology & Neuropathology of AD

QuestionAnswer
Amyloid Precursor Proteins (APP) The proteins involved in the accumulation of β-amyloid , which stick together when improperly folded, causing neuronal death.
Neurofibrillary Tangles (NFTs) The result of misfolded/ hyperphosphorylation of tau proteins, specifically paired helical filaments.
Tau Proteins Peptides that form microtubles helping cell structure & function.
ACh Acetylcholine: a neurotransmitter released from Cholinergic neurons; ACh is involved with cognitive functions & memory.
AChE Acetylcholinesterase is an enzyme that breaks down acetylcholine, terminating its action at the synapse. This process is crucial for proper neurotransmission regulation in the nervous system.
After hypo/ hyper-phosphorylation , these specific proteins begin to aggregate and clump. β-amyloid
Primary neurons affected from Alzheimer’s Disease. Cholinergic Neurons
APOE e4 allele The APOE e4 allele is a genetic variant associated with an increased risk of developing Alzheimer's disease. It's a specific form of the apolipoprotein E (APOE) gene.
Created by: Khendriix
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