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Phagocytosis-General
Phagocytosis
| Term | Definition |
|---|---|
| Phagocytosis-General Term info | -This is the principle mechanism for "DC" and "Neutrophils" -A process where immune cells "eat" pathogens |
| Phagocytosis- Process | -Engulfed pathogen is enclosed in a "membrane-bound vesicle" referred to as the phagosome -Other vesicles (lysosomes) containing --> "antimicrobial peptides and cytotoxic enzymes" fuse with the phagosome -Lysosome + Phagosome = Phagolysosome |
| Phagocytosis- Why phago alone not kill? | -Just being in phagosome not enough to kill pathogen -result of lysosome content & other physiological process w/in phagolysosome -The lysosome fusing with the phagosome exposes the patho. to toxic attacks thus killing it w/in the phagolysosome |
| Phagocytosis- Other Physiological Processes(List) *(ROS, RNS)* | -Acidification -Enzymes -Anti-microbial peptides -Metabolic Competitors -Reactive Oxygen & Nitrogen Species |
| Phagocytosis- Acidification | -Pump H+ ions into the phagosome-[each phago. almost as acidic as stomach] -pH = 3.5-4.0, bacteriostatic (suppress growth of bacteria) or bactericidal (kill the bacteria) |
| Phagocytosis- Enzymes | -Actively cut up other proteins, lipids, sugars, molecules, and actively begin digesting the particle |
| Phagocytosis- Anti-microbial peptides (and defensins) | |
| Phagocytosis- Metabolic Competitors | -Steal iron from the pathogens so that they can't "use it to metabolize and replicate" |
| Phagocytosis- ROS and RNS | -These are incredibly toxic to pathogens |
Created by:
CottonPi_24
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