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HemeTest2

Hematology Test #2

QuestionAnswer
Yellow marrow Storage organ and reserve of hematopoietic tissue
Red marrow Provides the supporting substance, growth factors, cytokines, and extra-cellular matrix.
Apoptosis induced by? Cytotoxic lymphocytes, anti-cancer drugs, G or UV radiation, a group of cytokines, and deprivation of survival factors.
Cells as apoptosis occurs Shrink, chromatin condenses, membrane blebs
Membrane made of? Glycoprotein for strength, and phospholipids for flxibility and barrier.
Microfilaments support and motility
Microtubules cells shape, motility, and mitotic process
Mononuclear phagocyte system bone marrow progenitors, blood monocytes, tissue macrophages
Splenectomy benificial in cases of excess rbc destruction. Increase in platelets
Cytokine soluable glycoproteins that modulate functional activities of cells. growth factors, interleukins, interferons, monokines, lymphokins, chemokines, colony stimulating factors
IL 1 multiple biological activity
IL 6 anti AML therapy (chemo)
Interferon hepatitis C
EPO produced in specialized kidney cells, responds to hypokia, effective in low conc, can increase the speed of development
TPO produced in specialized liver cells
indications of increased intravascular disease down: hapotglobin and hemopexin. Up: retics, LDH iso's 1 and 2, bone marrow production, iron stores, indirect bilirubin
Pyruvate Kinase prevents hemolytic anemia
2,3 BPG helps with O2 release
Hexose monophosophate shunt converts glocose to pentose while releasing NADPH. Needs G6PD to function
G3PD catalyzes NADH
NADPH reduces glutathione which protects cells from oxidative injury
key rate limiting step in formation of hemoglobin initial reaction with glycine and succytl coa to form ALA
clotted marrow placed in? ferratin of B5
AML size: large Cytoplasm: abundant Chromatin: fine Nucleoli: Predominant Auer Rods: Present >50%
ALL Size: small Cytoplasm: Scant Chromatin: Varies Nucleoli:Inconspicuous Auer rods: Absent
Created by: ardevlin
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