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Ch. 5: Integumentary
| Question | Answer |
|---|---|
| What are the organs in the system | Skin, skin appendages |
| What are the layers found in the skin? | Epidermis: Dermis: 2 types: Avascular Hypodermis |
| Epidermis | Stratified (lots) squamous (flat) layer Dermis: 80% of skin, 2 types: Thin and thick Avascular: no blood vessels, fed by diffusion Hypodermis: subcutaneous layer, not part of the kin |
| Dermis | 80% of skin, |
| 2 types of skin | Thin and thick |
| avacular | no blood vessels, fed by diffusion |
| hypodermis | subcutaneous layer, not part of the kin |
| What is the structure of skin? | Epidermis – keratinized, stratified, squamous epithelium |
| What are the types of cells found in the epidermis? | 4 types of cells Melanocytes Keratinocytes Touch receptors(Merkel disc) Dendritic cell |
| Melanocytes | deepest layer, synthesize melanin protects nucleus from UV rays move along cell process melanin made by melanosomes |
| Keratinocytes | Keratinocytes: make keratin=intermediate filaments Connected by desmosomes Divided rapidly, die and rub off New skin ~30 days |
| Touch receptors (Merkel cells) | sensory nerve ending Tactile cell and touch disc |
| Dendritic cell | langer’s cell Type of macrophages Phagocytic immune cell Form bone marrow |
| What are the layers of cells in the epidermis (deep-superficial) | 5 layers Stratum Basale Stratum Spinosum Stratum grandulosum Stratum Lucidum Stratum Corneum |
| Stratum Basale | (stratum germinatiuum) Single row Rapidly dividing cells 20% melanocytes Few tactile receptors |
| Stratum Spinosum | (prickly) 2-3 rows of cells Several layers thick Dendritic cells Looks spiked when fixed |
| Stratum Granulosum | Granular layer 1-5 layers Cells flatten Contains Grandules and glycolipids Fill with keratin keratinhyline → crosslinks keratin Melane breaks down Release inter extracellular space→ waterproofing |
| Stratum Lucidum | Thick skin only 2-3 rows/layers Clear, flat dead keratinocytes “Clear layer” |
| Stratum Corneum | 20-30 layers of cells apoptosis - annulated and flat ⅔ of epidermal thickness Cells flake off Glycolipids (waterproof) Keratin + plasma membranes- protect from abrasion |
| What are the structures of the Dermis? | Cells: Matrix: Dermal Layers: Dermal ridges: Reticular layer: Hypodermis: |
| Cells (dermis) | Fibroblasts: make fibers Macrophages: dispose of dead cells + foreign invaders Misc. cells: WBCs, mast cells |
| Matrix | Ground substance- semi fluid Fibers- collagen, elastin, reticular Lots of blood vessels, lymph vessels, nerves |
| Dermal Layer | 2 layers → papillary and reticular |
| Dermal ridges | part of papillary Epidermal ridges “Fingerprints” |
| Reticular layer | dense irregular CT 80% Nourished by cutaneous plexus Cleavage lines - less dense CT, heals better Flexure lines - dermal fold near joints, skin attaches Lamellar (Pacinian, lamellated) corpuscles - pressure |
| Hypodermis | Subcutaneous, superficial fascia (not part of skin) Areolar CT Adipose- shock absorber, gain weight |
| Dermis HI | Blister: separation of dermis + epidermis by fluid Striate: dermal tearing, caused → skin stretches, leaves scars |
| What are the substances that contribute to skin color? | Carotene Melanin Hemoglobin |
| Carotene: | yellow/orange pigment accumulate in stratum corneum + hypodermis, convert into vit. a |
| Melanin: | polymer of tyrosine Reddish yellow → brownish black Variations: all same # of melanocytes Variations is caused by type of melanin, amount made + retain Freckles + moles = accumulation of melanin |
| Hemoglobin: | in dermal capillaries = “pinkish hue” |
| Skin Color HI | Main factor: Sun Cause DNA damage → melanocytes make more melanosomes - protect the nucleus from UV Sun damage Damage DNA → cancer Clumps elastin → leathery skin |
| What are the structures of Hair and hair follicle | Shaft: Root Layers Medulla: large cells, air spaces, soft keratin Cortex: several layers of flat cells Cuticle: single layer of overlapping cells, hard keratin → wears off + split ends |
| 2 types of hair | Vellus: fine body hair of women + kids - has no medulla Terminal - coarser, darker scalp , eyebrow Post puberty: male body, axilla and pubic hair |
| growth cycles | Active phase= eyebrow ~ 3 months, scalp ~ 6-10 yrs Regressive phase= matrix dies, hair falls out, lose ~90/day Resting phase = 1-3 months, new hair forms Hair has limited # of cycles w/ age → thinning w/ age terminal hair replaced with vellus |
| Male pattern baldness | Sex-linked, genetic |
| Hair HI | Hirsutism Excessive hair growth Due to excess androgens |
| What are the parts of a nail? | Free edge Body – hard keratin Root Bed Matrix Lunule Eponychium Hyponychium |
| What types of glands are found in the skin? | Sweat glands = sudoriferous Apocrine glands Ceruminous glands – make cerumen Mammary glands Sebaceous glands |
| Sweat glands | sudoriferous 2 modified 3 million, except lips + parts of genital Eccrine glands apocrine glands |
| Apocrine glands | 2,000 Axillary & genital Open into hair follicle Sweat, fats & proteins (+ bacteria = body odor) → viscous yellowish, odorless until acted on by bacteria (BO), start functioning at puberty due to testosterone, Acted by SNS |
| Ceruminous glands | make cerumen = earwax, deter insects |
| Mammary glands | secret milk |
| Sebaceous glands | -oil glands Secrete sebum – oils + cell fragments into hair follicle Lubricates hair and skin Slows water loss Kills bacteria Release stimulated by testosterone Not found in thick skin |
| What are the functions of the integumentary system? | Protection Chemical barrier |
| What happens when things go wrong? | Skin Cancer Benign tumor – wart, callus Malignant Burns |
| What are the developmental aspects of skin? | Embryology: 3 germ layers Ectoderm: nervous system epidermis Mesoderm: dermis + hypodermis Endoderm: get, rerp. |
| What happens in aging? | skin thin increase in bruising, dry itchy Elastic fibers clump Collagen stiffens Decrease in subcutaneous fat All contribute to wrinkles Hair: thins |
| What is in papillary layer? | areolar CT Dermal papillae Capillary loops Free nerve endings - pain Tactile (Meissner's) corpuscles - touch Dermal ridges Epidermal ridges “Fingerprints” |
| Hair is not located | Thick skin, nipples, parts of genitals |