Save
Busy. Please wait.
Log in with Clever
or
show password
Forgot Password?
Don't have an account?  Sign up 
Sign up using Clever
or
Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account. Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't Know
Remaining cards (0)
Know
0:00
edit
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Path-Splenomeg/Hyper

QuestionAnswer
The clinical picture of hypersplenism is dominated by what specific causal condition of the splenomegaly? Liver cirrhosis
What are the SS of chronic liver disease-cirrhosis? jaundice, dark urine, esophageal varices, peritoneal fluid, results of blood chemical studies showing hepatocellular injury and dysfunction
What are the SS of splenomegaly and hypersplenism? mass in the left hypochondrium tender to palpatation, bruises, decreased platelet count, decreased wbc count, decreased rbc and decreased hemoglobin
Hypersplenism is a syndrome in which circulating cytopenia is associated with splenomegaly.
The cardinal features of hypersplenism are: splenomegaly; reduced levels of one or more blood cell elements, resulting in anemia, leukopenia, thrombocytopenia or any combination, iaw hyperplasia of the marrow precursors of deficient cell type; correction of cytopenia by splenectomy.
A normal spleen weighs ___g, and is approximately ____cm 150g, 11-12cm
The splenic artery enters the capsule at the hilus and branches into __________ arteries, which then branch into _______arteries and enter the _______ trabecular, central, white pulp
White pulp is composed of? Lymphoid tissue
Red pulp consists of? vascular sinusoids, the splenic cord (the cords of Bilroth) and the terminal branches of the penicillary arteries.
The endothelial lining of the sinusoid is of the open or discontinuous type
What is the benefit of slow circulatin through the red pulp? macrophages lining the cord remove damaged or aged cells.
What is the wt of a palpable spleen? One that is in splenomegaly? And a massive splenomegaly? 750-1000 g, 400-500 g, than 1000 g
What are the functions of the spleen? Hematopoeisis, removal of damaged and aged red blood cells and platelets, immunologic function, storage of cells
What is Extramedullary hematopoiesis? It is the use of the spleen hematopoiesis, it is a significant cause of splenomegaly in bone marrow diseases and chronic hemolytic anemias.
What are the four etiologic groups of splenomegaly considered important? congestive, inflammatory, hyperplastic, and infiltrative
Describe Congestive splenomegaly This form develops as a result of liver cirrhosis with portal vein hypertension and splenic vein thrombosis.
Describe Inflammatory splenomegaly. develops iaw various infections, inflamm or immuno processes (malaria, SLE). Inc. antigen clearance from blood leads to inc. macrophagal cells in spleen and stimulates accelerated production w/ resultant lymphoid hyperplasia and splenomegaly.
Describe Hyperplastic splenomegaly. Thought to reflect hypertrophy from work overload resulting fropm the removal of abnormal red blood cells from the circulation (hereditary spherocytosis, thalassemia) or, in some cases as the result of extramedulary hematopoiesis.
Describe Infiltrative splenomegaly. This condition develops as a result of engorgement of macrophages with indigestible materials (e.g., Gaucher disease).
What is important in determining the degree of red blood cell sequestration? It is the size of the spleen not the portal pressure.
Splenomegaly (splenic hypertrophy) results in ... both sequestration of formed elements and premature destruction of blood cells by splenic macrophages. Because normal function of splenic macrophages is removal of senescent rbcs, this is an exaggeration phys process for splenic macrophages.
enlarged spleen can also trap and remove platelets and white blood cells, so that anemia may be associated with what? varying degrees of thrombocytopenia and leukopenia.
The most common symptoms of splenomegaly with hypersplenism are: Enlarged spleen (palpation); vague Abd pain -lt hypochondrium; Low granulocyte count, infections when <1000/mm3 (norm 4,500 – 11,000); Low plat count manifested as bruises (purpura) or mucosal bleeding; Low rbcs manifested as pallor, dyspnea or fatigue.
How is hypersplenism treated? Successful tx of underlying disorder can lead to regression of splenomegaly /hypersplenism w/o surgery, splenectomy may be best tx and helps to control basic disease, life-threatening infections represent a major sequela after splenectomy.
What is liver cirrhosis? damage to liver cells from hepatitis viruses, alcohol, metabolic derangements or other. Dead cells are replaced by fibrous tissue -fibrosis scarring. Remaining cells regenerate in abnormal pattern, forming nodules that are surrounded by fibrous tissue.
How is liver cirrhosis characterized? by widespread nodules in the liver combines with widespread fibrosis; fibrosis and nodule formation causes distortion of the normal liver architecture which interferes with blood flow through the liver.
Dec blood flow through cirrhotic liver causes what organ to becom enlarged? spleen
What is the difference in appearance between normal spleen and splenomegaly? slate gray w/ red perenchyma vs tan-white fibrous plaques over purple surface
Created by: jpop
Popular Medical sets

 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!
"Know" box contains:
Time elapsed:
Retries:
restart all cards