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PATH: Disease II
Diseases only
| Question | Answer |
|---|---|
| intraductal papilloma | large duct with subaereolar location and discharge |
| who gets intraductal papillomas | women in their 50s (younger women may have them in smaller ducts) |
| are intraductal papillomas benigh or malignant | beign but may have a carcinoma in situ |
| what is the lining of the intraductal papilloma | epithelial and myoepithelial cell linings |
| nipple papilloma | subaereolar mass with discharge and errosion that looks like Padget's disease |
| what is the histology of nipple papilloma | papillary architecture with myoepithelial cells |
| what are the carcinomas in situ of the breast | ductal, lobular and padgets |
| what is ductal carcinoma in situ | ductal type carcinoma confined in the cells |
| how is ductal carcinoma distributed | usually unifocal with risk on the ipsilateral side |
| what carcinoma in situ makes you watch only the affected side | ductal carcinoma in situ |
| all carcinoma in situs have? | microcalcifications |
| what can increase the risk of invasion with ductal carcinoma in situ | comedo necrosis with microcalcifications in debris |
| what is the most important risk determinant with carcinomas in situ | grade |
| how are lobular carcinomas in situ distributed | multifocal with worry about both breasts |
| which in situ carcinoma makes you worry about both breasts | lobular carcinoma in situ |
| what percent of lobular carcinomas in situ are bilateral | 30-40% |
| lobular carcinoma in situ may leads to? | invasive lobular or ductal carcinoma |
| padgets disease | tumor confined in the epithelium of the nipple |
| what does pagets disease look like | nipple ulcerated with eczema like changes |
| padges is usually associated with? | underlying carcinoma |
| 50-70% of invasive breast cancers are? | invasive ductal carcinomas |
| how do invasive ductal carcinomas present | mass in cords, nests, or tubules |
| what is the second most common invasive carcinoma of the breast | invasive lobular carcinoma |
| how do invasive lobular carcinomas present | not as a mass they are too diffuse and lack desmoplasia (fibroblasts) |
| how do malignancies of Lobular invasive carcinoma arrange themselves | small malignancies in tiny cords single file |
| 10 percent of invasive lobular carcinomas can produce a carcinoma on what side | same or opposite |
| besides invasive lobular and ductal what are the other invasive carcinomas | medullary, tubular, mucinous |
| inflammatory carcinoma | not distinct but appears a a peu de orange with spread over the skin of the breast |
| how long does someone with inflammatory carcinoma live | less than 2 years usually |
| Phylloid turmo | leaf like tumor that occurs around age 45 with hypercellualar overgrowth of bland ductal elements |
| what is gynecomastia | gland or stromal hyperplasia in men |
| what are some causes of gynecomastia | increased estrogen, decreased androgen, cirrhosis and estrogen therapy |
| when does gynecomastia start to present | at puberty there is usually also hypogonadism |
| what syndrome is associated with gynecomastia | kleinfelter's syndrome |
| what percent of all breast cancer are men | 1% |
| what increases a man's chance of having breast cancer | age and klinefelters syndrome |
| how do men with breast cancer present | nipple abnormalities (maybe discharge or breast abnormality |
| prognosis in men depends on? | STAGE |
Created by:
jmuame03
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