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Bact: stupid drugs


drugs that alter the bacteria cell wall fosfomycin, cycloserine, vancomycin, bacitracin, B lactams
how does fosfomycin work binds covalently to muramic acid synthesizing enzyme to inhibit synthesis of Muramic
how are bacteria developing fosfomycin resistance decreased uptake
how does cycloserine work? inhibits synthesis of D-ala D-ala
how are bacteria becoming resistant to cycloserine decreased uptake
how does vancomycin work binds D-ala D-ala and prevents transglycosylation
how are bacteria becoming resistant to vancomycin they alter D-ala D-ala to make it D-ala-D lactate
who is especially resitant to vancomycin enterococcus
how does bacitracin work blocks dephosphyorylation of lipid carriers
what does bacitracin and vancomycin work against Gram +
how does b lactams work inhibits PBP which carry out crosslinking, it inhibits transpeptidation
are B-lactams bacteriocidal or bacteriostatic cidal
what does the b lactam ring mimic the D-ala D-ala of the peptidoglycan precursor
how do b lactams differ different side chains same nucleus
who are two b-lactamase inhibitors clavulanic acid and sulbactam
What drugs work on cell membrane polymyxin
how does polymyxin work cationic detergent that binds LPS
how is polymyxin applied topical kills even non-dividing gram neg bacteria
what drugs work on the DNA structure nitrofuantoin adn metronidazole
how do drugs that work on the DNA structure function the nitro group is reduced by a nitroreductase and makes a reactive species that cleaves DNA
nitrofurantoin and metroniadazole are only effective against? anaerobes
what drugs alter DNA synthesis quinolones, fluoroquinolones
how do drugs that alter DNA synthesis work? inhibits DNA gyrase, topoisomerase II blocks DNA supercoiling
how are bacteria resistant to quinolones alter target
what drugs alter RNA synthesis Rifamycins
how does rifamycin work blocks RNA polmerase
how does resistance to rifamycin work alter B subunit of RNA polymerase
drugs that alter protein synthesis are static or cidal static
what drugs affect the 50S ribosomal unit chloramphenicol, macrolides (azithromycin, erythromycin, clarithromycin), lincosamides
how do choramphenicols work bind reversibly to exit tunnel of 50s
how do the macrolides work (erythro, azithro, clarithro) block translocation and elongation
how does resistance develope to macrolides alter target
how do lincosamides work binds 50S and blocks peptide bond formation
how does tetracyclin work stops tRNA from binding
who should not get tetracyclin pregnant women and children (bone seeking)
how have bacteria become resistant to tetracyclin decreased uptake increased efflux
how do aminoglycosides work bind irreversibly to 30S
what is special about aminoglycosides they are bacteriocidal
when are aminoglycosides useful anerobic conditions
how are bacteria becoming resistant to aminoglycosides alter target, inactivate the drug, decrease uptake
how does bactrim work inhibits thymine synth via blockage of dihydropteroate synthetase
is bactrim static or cidal static
how has resistance developed to bactrim alter target, decrease uptake, increase level of target enzymes
how does trimethoprim work inhibits thymine synth
how are bacteria becoming resistant to trimethoprim increase level of targer or alter target
what does isoniazid do inhibits mycolic acid synthesis
when is mycolic acid important M. Tb
prblem with isoniazid hepatotoxic
Created by: jmuame03