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BACT. B. Burgdorferi
DD Borelia
| Question | Answer |
|---|---|
| how do spriochetes get around | endoflagella very motile and trapped in the periplasm |
| how do you see borrellia | IF |
| b. burgdorferi causes | Lyme |
| Hermsii and recurrentis | relapsing fever |
| Treponema pallidum causes? | syphyllis |
| leptopira interogans causes? | leptospirosis |
| of the spirochetes which are zoonoses | borrelia and leptospira |
| how is borellia different from other spirochetes | larger and more narrow |
| what are the acute form syptoms associated with borrelia | fever, bull's eye, muscle pain, with meningeal irriation |
| what are the chronic form symptoms of borrelia | meningioencephalitis, myocarditis, disabling recurrent arthritis |
| what percent of borrelia patients get erythema migrans | 70-90% |
| is the lesion asymptomatic | no it burns |
| what other symptoms are common with borrelia | flu like symptoms |
| what percent of patients have symptoms that continue | 73% |
| when does stage 2 start | onset to 4 months |
| what percent in stage 2 have disseminating spirochetes | 73% |
| what else is common in stage II | neurologic symptoms, carrdiac (myocarditis) and systemic (malise fatigue) |
| when does stage 3 happen | 5 to 24 months |
| what percent of untreated go onto stage III | 50-60 % |
| what percent have migrating arthritis and synovitis | 10% |
| with the migrating arthritis is it sterile or bacteremic | sterile so likely an immune process |
| where is the borrelia likely to stay | in areas with poor immune system response like the brain, nervous system, joints, skin |
| when is the infection commonly spread | april through september |
| how long do the ticks have to feed to be infectious | 40-60 hours |
| what is the exotoxin of borrelia | LOS lipid A elicits a weak response |
| what are the two virulence factors of borellia | OspA common as the tick starts to feed becomes OspC as bacteria enters mammal |
| why no vaccine against OspA | cross rx |
| why no vaccine against OspC | too variable |
| what does vaccine against OspA work against | antigen 1 (hLFA-1) especially in people with HLA-DR4 |
| how do you diagnose someone with Lymes early? | exposure and clinical symptoms |
| how do you diagnose someone with lyme late | serology, elisa, IF |
| what is the problem with testing for borrelia | can have positives based on cross rx |
| most common vector disese in the us | Borrelia |
| the Ixodes tick scapularis is in the | East |
| Ixodes pacificus is in the | West |
| Treatment | doxycyline, amoxicillin, cefuroxime |
| O2 requirements of borellia | microaerophilic |
| tight or loose spirchete | loose with irregular coils |
| genome of borrellia | 9 linear 2 circular plasmids |
| why can't you just fight the bacteria | constantly changing its surface |
Created by:
jmuame03
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