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Bone tissue

Bone or osseous tissue -dense supportive connective tissue -contains specialized cells -composed mostly of solid extracellular matrix with college fibers
Inorganic matrix 65% of total bone weight, composed of minerals
Organic matrix 35% of bone total weight, composed of college and other ECM components
Dense matrix Deposit of calcium salts
Osteocytes (bone cells) Within lacunea organized around blood vessels
Canaliculi Narrow passageways that allow for exchange of nutrients, wastes, and gases between osteocytes.
Periosteum -covers outer surface of Bones (except joints) -consists of outer fibrous and inner cellular layers -connected to bone by perforating fibers
Perforating fibers Collagen fibers
What makes up almost 2/3 of bone Mass? Calcium phosphate Ca3(PO4)2
How much of the body calcium is stored in bone? 85%
Hydroxyapatite Mixture of calcium phosphate and calcium hydroxide and is a formed Crystal.
What makes bone one of the strongest and hardest substances of the body? Crystalline structure
Characteristics of a bone lacking a calcified matrix Looks normal but is very flexible
Organic bone matrix (osteoid tissue) composed of? -protein fibers -glycosaminoglycans -proteoglycans -glycoproteins
How much of the bone Mass is callogen fibers? 1/3
What is torsion Twisting
What is tensile Stretching
What help draw water into the osteoid matrix? Glycosaminoglycans and proteoglycans
Bone cells make up how much percent of bone Mass? 2%
What are the 4 types of bone cells -osteogenic -osteoblasts -osteocytes -osteoclasts
Functions of osteogenic cells -mesenchtmal stem cells that divide to produce osteoblasts -located in inner cellular layer of periosteum and in endosteum -metabolically and mitotically active -assist in fracture repair
Osteogenic cells Stem cells whose divisions produce osteoblasts
Osteoblasts Bone building cells -immature cells that produce new bone matrix during osteogenesis (ossification) - surround themselves themselves with home material and become osteocytes
Osteoid Matrix produced by osteoblasts that has not yet become calcified
Osteocytes Mature bone cells that are surrounded in bone matrix. -less metabolically active, but still critical for maintaining bone matrix -remain interconnected via cytoplasmic extensions that pass through canaliculi
Major functions of osteocytes -maintain protein and mineral content of matrix -help repair damaged bone
Osteoclasts (bone dissolving cells) -large and are multinucleated -dissolve and remove bone matrix -secrete about and protein-digesting enzymes
What is a resorbtion Bay? Where osteoclasts are located in shallow depressions of external bone surface
Osteolysis Bone degredation by osteoclasts
Created by: Garciamentzer