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|What is the maximum volume of blood that can be collected from a 110-lb donor, including samples for processing?
|How often can a blood donor donate whole blood?
|every 8 weeks
|When RBCs are stored, there is a "shift to left". This means:
|Hemoglobin oxygen affinity increases, owing to a decrease in 2,3 DPG
|The majority of platelets transfused in the United States today are:
|What anticoagulant preservative provides a storage time of 35 days at 1 degree Celsius to 6 degrees Celsius for units of whole blood and prepared RBCs if an additive solution is added?
|CPDA-1 Citrate Phosphate Dextrose Adenine 1
|What are the current storage time and temperature for platelet concentrates and apheresis platelet components?
|5 days at 20-24 degrees Celsius
|What is the minimum number of platelets required in a platelet concentrate prepared from whole blood by centrifugation? (90% of sampled units)
|5.5x10 to the 10th power
|RBCs can be frozen for
|What is the minimum number of platelets required in apheresis component (90% of the sampled units)
|3x10 to the power of 11
|Whole blood and RBC units are stored at what temperature?
|1-6 degrees Celsius
|Additive solutions are approved for storage of RBCs for how many days?
|One criterion used by the FDA for approval of new preservation solutions and storage containers is an average of 24-hour post-transfusion RBC survival of more than:
|What is the lowest allowable pH for a platelet component outdate?
|Frozen and thawed RBCs processed in an open system can be stored for how many days/hours?
|What is the hemoglobin source for hemoglobin-based oxygen carriers in advanced clinical setting?
|Bovine and Human hemoglobin
|What occurs during storage of RBCs?
|Nucleic acid amplification testing is used to test donor blood for?
|HCV HIV West Nile virus
|It is not an FDA-approved test for quality control of platelets?
|Prestorage pooled platelets can be stored for:
|What is most common cause of bacterial contamination of platelet products?
|Entry of skin plugs into the collection bag
|What best describes mitosis?
|Genetic material is duplicated, equally divided between two daughter cells
|When a recessive trait is expressed, it means that:
|Two genes carrying the trait were present.
|In a pedigree, the "index case" is another name for:
|What are the four nitrogenous bases of DNA?
|Adenine Cytosine Guanine Thymine
|What phenotype(s) could not result from the mating of a Jk(a+b+) female and a Jk(a-b+) male?
|Exon refers to:
|The coding region of a gene.
|PCR technology can be used to:
|Amplify small amounts of DNA
|Transcription can be defined as:
|Synthesis of RNA using DNA as template.
|When a male possesses a phenotypic trait that he passes to all his daughters and none of his sons, the trait is said to be:
|When a female possesses a phenotypic trait that she passes to all of her sons and none of her daughters, the trait is said to be:
|DNA is replicated to:
|Semiconservatively from DNA
|RNA is processed:
|after RNA is copied from protein on ribosomes
|Translation of proteins from RNA takes place:
|On the ribosomes in the cytoplasm of the cell
|Meiosis is necessary to:
|Generate new DNA sequences in daughter cells
|Proteins and peptides are composed of:
|Linear arrangements of amino acids
|Patient cells with Anti-A 4+ Anti-B 4+ A1 cells NEGATIVE B cells NEGATIVE What is the patient's blood type?
|The major immunoglobulin class of anti-B in a group A individual is:
|What are the possible ABO phenotypes of the offspring from the mating of a group A to group B individual?
|What ABH substance(s) would be found in the saliva of group B secretor?
|H and A
|What ABO blood group contains the least amount of H substance?
|An example of a technical error that can result in an ABO discrepancy is:
|Cell suspension is too heavy
|What best describes Lewis antibodies?
|IgM, naturally occuring, do not cause HDFN
|The Le gene codes for a specific glycosyltransferase that transfers a fucose to the N-acetylglucosamine on:
|Type 1 precursor chain
|What substances would be found in the saliva of a group B secretor who also has Lele genes?
|Transformation to Lewis B phenotype after birth may be as follows:
|Le(a-b-) to Le(a+b-) to Le(a+b+) to Le(a-b+)
|In what way do the Lewis antigens change during pregnancy?
|Lewis A and B decreases
|A type 1 chain has:
|The terminal galactose in a 1-3 linkage to subterminal N-acetylglucosamine
|What best describes Lewis antigens?
|The antigens are integral membrane proteins.
|What genotype would explain RBCs typed as group A Le (a+b-)?
|A/A LeLe hh sese
|What best describes MN antigens and antibodies?
|Well developed at birth, susceptible to enzymes, generally saline reactive
|What autoantibody specificity is found in patients with Paroxysmal Cold Hemoglubinuria?
|What is the most common antibody seen in the bloodbank after ABO and Rh antibodies?
|What blood group system is associated with resistance to P.vivax malaria?
|The null K0 RBC can be artificially prepared by which treatments?
|DTT and glycine-acid EDTA
|What antibody does not fit with the others with respect to optimum phase of reactivity?
|What Duffy phenotype is prevalent in blacks but virtually nonexistent in whites?
|Antibody detection cells will not routinely detect which antibody specificity?
|Antibodies to antigens in which of the following blood groups are known for showing dosage?
|What antibody is most commonly associated with delayed hemolytic transfusion reactions?
|Anti-U will not react with which RBCs?
|A patient with a Mycoplasma Pneumoniae infection will most likely to develop a cold autoantibody with specificity to which antigen?
|What antigen is destroyed by enzymes?
|The antibody to this high-prevalence antigen demonstrates mixed-field agglutination that appears shiny and refractile under the microscope:
|What is associated with causing severe immediate HTRs?
|What antibodies are more likely to be found in a black patient?
|Anti-CrA Anti-Ata Anti-Hy
|A weakly reactive antibody with a titer of 128 is neutralized by plasma. What could be the specificity?
|An antibody reacted with untreated RBCs and DTT-treated RBCs but not with ficin-treated RBCs
|Antibodies that are clinically insignificant because they have not been associated with causing increased destruction of RBCs, HDFN, or HTRs.