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anatomy
| Question | Answer |
|---|---|
| within muscle is innermost connective tissue layerthat surrounds each muscle cell fiber | endomysium |
| around muscle: surrounds bundles of muscle fibers called fascicles. dense irregular connective tissue that surrounds whole skeleton | perimysium |
| upon muscle: a layer of dense irregular connective tissue that surrounds whole skeletal muscle | epimysium |
| ___ stimulare muscle fibers to contract | moror neurons |
| highly ordered repeating units of myofilaments | sarcomeres |
| two strands of ___ form a double helix extending the length of the actin myofilament | F actin (fibrous) |
| ___: an elongated protein winds along the groove of the F actin double helix | tropomyosin |
| ___ is composed of 3 subunits: one that binds to actin, a second that binds to tropomyosin, and a third that binds to calcium ions | troponin |
| the _____ complex regulates the interaction between active sites on _____, _____ | tropomyosin/troponin complex, G actin, myosin |
| ___: filamentous network of protein. serves as attatchment for actin myofilaments | Z disk |
| from Z disks to ends of thick filaments | I bands |
| length of thick filaments | A bands |
| region in A band where actin and myosin don't overlap | H zone |
| middle of H zone, delicate filaments holding myosin in place | M line |
| in muscle fibers, __ and __ bands of parallel myofibrils are aligned | A and I |
| elastic chains of amino acids; make muscles extensible and elastic | tetin filaments |
| actin myofilaments sliding over myosin to shorten sarcomeres | sliding filament model |
| ___ system controls contraction through ____ ____ | nervous, action potentials |
| ligands are molecules that bind to receptors: ex: neurotransmitters | ligand-gated |
| open and close in response to small voltage changes across plasma membrane | voltage-gated |
| inside of plasma membrane becomes less negative. if change reaches threshold ___ occurs | depolarization |
| return of resting membrane potential. | repolarization |
| spread from one location to another. action potential doesnt move along the membrane; new action potential at each successive location | propagate |
| number of action potential produced per unit of time | frequency |
| ___ muscle: voluntary | skeletal |
| origin in primary motor ends | coricospinal neurons |
| extrapyramidal neurons: ___,___,___,___ | tectospinal, vestibulospinal, rubrospinal, reticulospinal origin |
| origin tectal region of midbraine | tectospinal |
| originin vestibular nuclei and cerebellum | vestibulospinal |
| origin in red nucleus of pons | rubrospinal |
| originin reticular formation of brain stem | reticulospinal |
| large type A myelinated nerves | spinal motor neurons |
| ventral horn of spinal cord | cell bodies |
| skeletal muscle fiber at the neuromuscular junction | final synapse |
| one sommatic motor neuron and all the skeletal muscle cells it stimulates | motor unit |
| one nerve cell supplies on average ___ muscle cells that all contract in unison | 150 |
| total strength of contraction depends on how ___ motor units are activated and how ___ the motor units are | how many,large |
| ___: axon terminal resting in an invagination of the sarcolemma. | synapse. |
| neuromuscular junction is made up of :. | presynaptic terminal, synaptic cleft, postsynaptic membrane (motor end plate). |
| ___: axon terminal with synaptic vesicles. | presynaptic terminal. |
| ____ blocks release of neurotransmitter at the NMJ so muscle contraction cannot occur | botulinum toxin |
| ____ is found in improperly canned food | bacteria (clostridum botulinum) |
| botulinum toxin: death occurs from paralysis of ____ | diaphragm. |
| derived from clostridum botulinum toxin | botox |
| plant poison used by s. american indians for poison arrows | curare |
| causes muscle paralysis by blocking ACh receptors, flaccid paralysis | curare |
| used to relax muscle during surgery | curare |
| antichoinesterase agent | neostigmine |
| blocks removal of ACh from receptors so strengthens weak muscle contractions of myasthenia gravis | neostigmine |
| antidote for curare after surgery is finished | neostigmine |
| inhibit Acherase, spastic paralysis of skeletal muscle | organophosphate |
| mechanism where an action potential causes muscle fiber contraction | excitation-contraction coupling |
| excitation-contraction coupling involves: | sarcolemma, transverse tubules, terminal cisternae, sarcoplasmic reticulum, triad, Ca2+, troponin |