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Immunology Exam2
| Term | Definition |
|---|---|
| IgG | can cross placenta, monomer, 37C, secondary response |
| IgM | primary response, pentamer, 22C |
| IgA | secretions, allergies |
| Antigen | substance that combines with an antibody |
| Allele | alternate gene |
| Immunoglobulin | protein secreted by plasma cell |
| Complement | proteins attached to RBCs |
| IgM and IgG | most common antibodies |
| AHG | prevents potential errors when typing |
| Dolichos Biflorus | reacts with A1 |
| Ulex Europaeus | reacts with H |
| Vicia Graminea | reacts with N |
| Iberis Amara | reacts with M |
| Rh and Duffy | chromosome 1 |
| MNS | chromosome 4 |
| Kell | chromosome 7 |
| ABO | chromosome 9 |
| Kidd | chromosome 18 |
| Lewis | chromosome 19 |
| P | chromosome 22 |
| Dosage | antibody reacts stronger with homozygous antigen than with heterozygous antigen |
| Hemolysis | destruction of RBCs, indicates positive result |
| LISS | decreases ionic strength, increasing antibody uptake rate |
| BSA | allows antibody-sensitized cells closer together |
| PEG | removes water molecules |
| Screening cells | detect unexpected antibodies, type O to possess relevant antigens |
| IgM cold antibodies | cause intravascular hemolysis |
| Rh null stomatocytes | Membrane abnormality that shortens RBC survival |
| LW | reacts with O pos, patient given Rh neg blood |
| Duffy | possible reason for black population resistance to malaria |
| Miltenberger | group closely related to MNS system |
| McLeod syndrome | no Kx antigen, reduced expression of other Kell antigens |
| Autoanti-P | causes PCH |
| P1 | hydatid cyst fluid antibody |
| Kidd | delayed transfusion reactions |
| High-titer, low avidity antibodies (HTLA) | detected at AHG phase, Chido (Cha) and Rodgers (Rga) |
| Antibodies to medication | suspected if nothing is found in elution |
| Low incidence antigens | antibody screen neg, but incompatible crossmatch |
| Adsorption | removing antibodies from serum |
| Elution | removing antibodies from RBCs |
| IAT | determines if antibodies to RBC antigens have been produced |
| DAT | determines whether auto or allo antibodies are present |
| Destroyed by enzymes | Fya, Fyb, S, M, N |
| Enhanced by enzymes | Rh, Kidd, Lewis |
| Allogenic | donation to general pool |
| Autologous | donation by patient for their own use later on |
| Segment | where blood is obtained for crossmatch |
| Landsteiner's Rule | if an antigen is not present on the cells then the corrosponding antibody will not be present in the patients plasma |
| 1-10C | temp at which blood is shipped |
| 5.5x10^10 | amount of PLTs that must be present per unit |
| ABO | blood group associated with intravascular hemolysis |
| Glycerol | protects against cell damage |
| Bacterial contamination in blood | P. Flourescens, P. Putida, Y. Enterocolitica, E. Cloacae |
| 3-4 days | transfusion time limit (effective limit) |
| IgG | involved in HDN |
| Rhogam | suppresses immune response |
| Rosette test (fetalscreen) | Fetomaternal hemorrhage screen |
| Kleihauer Betke test | quantify number of fetal cells in maternal circulation |
| Intrauterine transfusions | correct anemia, prevent heart failure |
Created by:
Ramin11
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