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Labetolol
Drugs
| Question | Answer |
|---|---|
| also known as | Trandate normodyne |
| Alpha1 blocking agent | vasodilation , decreased peripheral vascular resistance , orthostatic hypotension |
| nonselective blocking agent | effects the SA, AV , ventricular muscle =bradycardia , delay in AV conduction , depressed cardiac contractility |
| More potent Beta Blocker than Alpha Blocker= | BP reduces without reflex tachycardia |
| Indication #1 | Hypertensive emergencies |
| Indication #2 | All patients with suspected MI and unstable angina (if not contraindicated) |
| Indication #3 | Useful as adjunctive agent with fibrinolitic therapy (may reduce nonfatal re-infaction and recurrent ischemia) |
| Indication #4 | To convert SVT (re-entry SVT , Afib, A flutter with RVR) to NRS or to slow ventricular response |
| Indication #5 | To reduce myocardial ischemia in AMI patients with elevated HR,BP or both |
| Class | Beta blocker |
| Contraindications | -Bronchial asthma -Uncompensated CHF -High Degree Heart Blocks (2nd and 3rd degree) -Cardiogenic Shock -Severe Bradycardia -Pulmonary Edema -Hypersensitivity |
| Side effects CNS | Anxiety ,Dizziness , Fatigue/Malaise , Headache ,Tremors ,Mental depression , Drowsiness ,Nightmares , Scalp tingling Side effects |
| Side effects CV | AVblocks-LT, bradycardia , Chest pain ,CHF-LT, Orthostatic hypotension ,ventricular dysrhythmias-LT, palpatations, peripheral edema , pulmonary edema , Coldextremities |
| Side effects EENT | double vision , dry burning eyes , sore throat , tinnitus , visual changes |
| Side effects GI | Diarrhea-C, Nausea -C, vomiting , Constipation , Taste disturbances |
| Side effects GU | Dysuria ,Ejaculatory Failure , Impotence |
| Side effect HEME | Agranulocytosis-LT |
| Side effects RESP | Bronchospasms-LT , dyspnea , wheezing |
| Side effect MS | Muscle cramps |
| Side effects SKIN | Fever , Pruritus , Rash , Uticaria |
| Precaution - use with caution in -COPD patients (nonallergic -bronchospastic disease) -Well-compensated patients with hx of heart failure -Pheochromocytoma -Impaired hepatic function -Impaired renal function ..... | -Jaundice -Diabetes mellitus -Peripheral Vascular Disease -Thyroid disease -Nitroglycerin my augment hypotensive effects |
| How supplied | 5 mg / ml (4,8,20,40 ml vials) |
| Administered | SLOW IVPand IV infusion |
| Initial Dose | 10mg SLOW IVP (over 1-2 minutes) |
| Subsequent dose | 10 to 20 mg every 10 minutes , prn |
| Total dose | 150 mg |
| IV infusion dose: MIX | 200mg/250cc |
| IV infusion dose : INFUSE AT | 2 to 8mg/ minute (Titrate to supine blood pressure) |
Created by:
bandam17
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