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Ch.4

Neurotransmitters and neuromodulators

termFunctions
Amino Acids Glutamate, GABA, Glycine
monoamines Dopamine, norepinephrine, serotonin, histamine
Peptides Endophines, Enkephalines
Glutamate excitatory; interacts with other neurotransmitter systems-(CNS)
GABA Inhibitory; interacts with other neurotransmitter systems-(CNS)
Acetylcholine (ACh) Learning, memory, and REM sleep-(CNS) muscle contraction-(PNS)
Dopamine Voluntary movement, attention, learning, reinforcement, planning, and problem solving-(CNS)
Norepinephrine/Epinephrine Viligance-(CNS) Autonomic nervous system regulation such as heart rate and blood pressure(PNS)
Serotonin Mood regulation, eating, sleep, dreaming, arousal, and impulse control (CNS) Involved in the enteric nervous system (digestive tract)-(PNS)
Histamine Wakefulness-(CNS) Immune response-(PNS)
Opiods Reinforcement, pain modulation-(CNS) Pain modulation-(PNS)
Endocannabinoids Appetite regulation-(CNS) Immune response-(PNS)
Glutamate synthesized from a precursor (glutamine) by an enzyme (glutaminase) in one step
Glutamate receptors 4 major types of receptors 1. NMDA 2. AMPA 3. kainate 4.Metabotropic
GABA primary receptor site-drug muscimol-agonist secondary receptor site - benzodiazepines
Monoamine family - 5 chemicals Dopamine, Norepinephrine, Epinephrine, Serotonin, Histamine
Catecholamines 1.Dopamine 2.Norepinephrine 3.Epinephrine
Indolamine Serotonin
Ethylamine Histamine
Tyrosine precursor for dopamine Amino acid obtained from diet
MAO destroys monoamines (Dopamine, NE and 5-HT)
Deprenyl antagonist - MAO inhibitor-blocks the destruction of dopamine
MAOI's agonists
Norepinephrine (NE) aka. Noradrenalin
NE synthesis occurs inside the vesicles- vesicles are filled with dopamine; then an enzyme converts DA into NE
axonal varicosities beadlike swellings of the axonal branches
NE release release from axonal varicosities
monoamine oxidase (type A) destroys excess NE in terminal buttons
andrenergic receptors metobotropic receptors (A1,A2, B1, B2) sensitive to norepinephrine and epinephrine produce both excitatory and inhibitory effects
locus coeruleus nucleus located in the dorsal pons (most important noradrenergic neurons)
noradrenergic neurons involved in sexual behavior and in the control of appetite
Serotonin (5-HT) aka (5-hydroxytryptamine)
Tryptophan precursor for serotonin
tryptophan hydroxylase enzyme that acts on tryptophan producing 5-HTP (5-hydroxytryptophan)
Created by: Dalea
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