click below
click below
Normal Size Small Size show me how
adrenal phys
physiology of adrenals
Question | Answer |
---|---|
glomerulosa | aldosterone |
fasciculata | cortisol |
reticularis | androgens (DHEA) |
21 carbon steriods | progesterone, deoxycorticosterone, aldosterone, cortisol |
21 carbon steriods | progesteron is the precursor for all 21 carbon steroids |
21 carbon steriods | hydroxylation at C21 gives deoxycorticosterone |
21 carbon steriods | hydroxylation at C17 produces glucocorticoids |
19 carbon steriods | have androgenic activity |
18 carbon steriods | have estrogenic activity |
glucocorticoids | oscillates with circadian rythem, highest at 8AM and lowest at 12PM |
ACTH | stimulates secretion in all zones fo the adrenal by stimulating cholesterol desmolase |
ACTH | up regulates it's own receptor |
cortisol | inhibits the secretion of CRH by negative feedback |
mineralocorticoid | increases renal sodium reabsorption, potassium secreation, and hydrogen secretion |
aldosterone | secretion is regulated by the renin-angiotension system, hyperkalemia increases aldosterone secretion |
glucocorticoids | stimulates gluconeogenisis by; increasing protein catabolism, decreasing glucose utilization, increases lipolysis |
glucocorticoids | anti-inflammatory effects are induces the synthesis of lipocortin which inhibits phospholipase A2), inhibits production of interleukin-2, inhibits release of histamine and serotonin |
glucocorticoids | suppress the immune response by inhibiting the production of IL-2 |
glucocorticoids | mantains vascular response to catecholamines by up regulating alpha 1 receptors |