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Path Y2B2

malaria feed on Hb of erythrocytes; p. vivax attach to rbc via Duffy blood group antigen protozoa
f. falciparum "malignant" form of malaria protozoa
f. falciparum PfEMP1 - makes rbc stick together (microcirulation disturbed) protozoa
babesiosis Ixodes sp. (hard tick); DD: lyme disease and/or erlichiosis, minority of pts will manifest mixed infections protozoa
leishmaniasis usu called by L.mexicanan and L. donovani; TX southward protozoa
leishmaniasis inflammatory papule which usu ulcerates, at the site of the bite (bagdad boil) followed by regional lymphadenopathy; parasite remains protozoa
visceral leishmaniasis (Kala Azar - India and Brazil) caused by L. donovani protozoa
visceral leishmaniasis Sx: papule at bite; asym., splenomegaly, anemia protozoa
visceral leishmaniasis result in intrauterine transmission and congenital visceral leishmaniasis and cutaneous leishmaniasis protozoa
visceral leishmaniasis disseminated can lead to multi-organ dysfxn and immune deficiency which predisposes to other infections protozoa
chagas disease infects leukocytes initally and other cells of the body after dissemination via blood and lymphatics protozoa
chagas disease infect myocardium; neurons of myenteric plexus -- esophagus, colon, ureters protozoa
chagas disease acute - inflammatory papule, lymphadenopathy, hepatospl.; latent - may last a few yrs; symptomatic - minority of pts: heart, bowel, CNS protozoa
chagas disease clinical manifestations often includes a combo of myocarditis, dilation of the esophagus, dilation of teh colon, and dilation of the ureter protozoa
strongyloidiasis autoinfection can lead to disseminated hyperinfection w/ invasion of a number of internal organs worm
strongyloidiasis in pt taking high doses of corticosteroids, chronic pneumonitis, incrased incidence of bac sepsis d/t bowel wall damage from invasive larvae nematode
strongyloidiasis only helminth able to complete entire life cycle in human host which can lead to autoinfection nematode
cysticercosis man ingests EGGS rather than encysted larva, becoming the intermediate (not definitive) host cestode
cysticercosis eggs rise larvae which penetrate the bowel (CNS, eyes, skeletal muscle, subq) cestode
neurocysticercosis high mortality rate and leads to the formation of multiple small cysts in the brain often exhibiting dystrophic clacification (seizures, hydrocephalus, chronic meningoencephalitis) cestode
echinococcus species larvae disseminate to the lungs and liver where they form hydatid cysts in humans (liver - multilocular) cestode
ecinococcus species larvae multiply in cysts which enlarge over yrs; can go to other organs cestode
schistosomiaiss trematode infections can be classified based on the tissue invaded by adult flukes (blood, liver, lung, intestine) trematode
schistosomiaisis "swimmer's itch" cercarial dermatitis trematode
schistosomiaisis Katayama syndrome (fever, lymphadenopathy, hepatospl.) trematode
schistosomiasis chronic form depends on tissue tropism of liver, intestinal, pelvic/urinary trematode
schistosomiaisis blood fluke, S. haematobium = squamous cell carcinoma of bladder trematode
schistosomal dermatitis non-path to humans as terminal hosts; enzymes for penetration cause intense inflammation and itching after abt 12 hrs trematode
lymphatic filariasis intense granulomatous inflammatory response leading to lymphatic channel obstruction and lymphedema (elephantitis) nematode
acquired toxoplasmosis injest meat, or ingest sporulated oocysts present in cat feces protozoa
acquired toxoplasmosis in immune deficient pts, it can lead to necrotizing lesions in the CNS, heart, lungs, eyes protozoa
acquired toxoplasmosis most common organ is CNS protozoa
congenital toxoplasmosis first trimester = low; second trimester = transmission to fetus almost always occurs, but effects on fetus are minimal protozoa
congenital toxoplasmosis toxoplasmosis triad: chorioretinitis, hydrocephalus, cerebral calcificaiton protozoa
entamoeba histolytica bowel mucosa ulcerations; 1 in 20 cases complicated by intestinal perforation protozoa
entamoeba histolytica amebic abscess in the liver; disseminated amebiasis is uncommon in immunocompetent, but does occur protozoa
entamoeba histolytica amebic colitis w/ mucosal inflammation and ulceration protozoa
entaoeba histolytica ameboma is tumor-like chronic inflammatory proliferation in the wall of the colon; systemic spread including lung, skin and liver protozoa
Giardiasis acute and chronic gastritis and/or enterocolitis but does NOT cause dysentery (blank)
trichomonas asym carriers; non-invasive infection in females (vaginitis) or males (urethritis); rarely causes cystitis in females or prostatitis in males (blank)
trichomonas strawberry cervix sign is highly correlated w/ T. vaginalis infection (blank)
cryptosporidiasis diarrhea; self-limited in immunocompetent; can lead to chronic diarrhea - malnutrition and dehydration via systemic dissemination (blank)
ascariasis chronic malnutrition; worms consume 10% of food (blank)
ascariasis intestinal obstruction due to heavy worm pop; infrequently causes bilary tract obstruction (blank)
enterobius vermicularis perianal pruritis (usu nocturnal) (blank)
hookworms serpiginous rash; cutaneous larva migrans (blank)
hookworms pneumonic phase; intestinal phase (iron deficiency anemia) -- sequele (blank)
cutaneous larva migrans self-limiting disease w/ cutaneous larvae dying and lesions resolving w/in 4-8wks (blank)
cutaneous larva migrans secondary bac infection is common (s. aureus or s. pyogenes) (blank)
clonorchiasis infects the bile passages; markedly increased incidence of suppurative cholangitis leading to acute biliary tract obstruction flukeworm
fascioliasis markedly increased incidence of suppurative cholangitis leading to acute biliary tract obstruction flukeworm
fascioliasis cliinal synopsis: spontaneous pneumothorax, chronic coughing, chronic dyspnea flukeworm
dermatobiasis botfly lays eggs on stomach of mosquite or other blood sucking insect (blank)
dermatobiasis eggs into human skin from bite; warble: larvae burrowed under skin (blank)
dermatobiasis NOT systemic, just remove from skin (blank)
scabies intense prutitis; linear erthematous lesions are often a/w inflammatory papules (blank)
scabies burrowing females avoid hairy areas: wrist, sides of fingers/feet, penis (blank)
Created by: fl_sun80