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Circulation regul.

Local regulation of blood flow.

QA
What are the two major autoregulation mechanism which controls the local blood flow! Metabolic and myogenic control.
What happens with increased BL through capillaries? Increased venous return-> Increased CO
Which two phases can the local blood flow control be divided in? 1)Acute - rapid change constriction/dilatation of arteriols, metarteriol et spincters 2)Long-term control provides a better control by increasing/decreasing the physical size and number of blood vessels supplying the tissues.
Which are the two basic theories for regulation of local blood control? 1)vasodilator theory (less availability of metabolit->formation of vasodilation substances like adenosine, CO2, AMP, histamine, K, H etc.) 2) Oxygen lack theory
What is hyperemia? Increased blood flow to organ or tissue.
What is reactive hyperemia? If blood suppy to a tissue is blocked for seconds or hours and the is unblocked there will be a blood flow 4X-7X the normal and lasts long enough to repay exactly the tissue oxygen dificient that has accord during the period of occulusion.
What is active hyperemia? Increased local metabolism -> decreased nutrition and increased vasodilation substances -> increased blood flow
Explain the metabolic theory! When arterial pressure becomes too great and we have to much flow to the tissue -> vasoconstriction.
Explain the myogenic theory! High arterial pressure -> vessel stretch -> vasoconstriction-> Blood flow back to normal (Can cause vicios circle)
Increased flow (shear stress) leds to? Inhibition of endotelin (production in endotels) -> relaxation of vessel
Why is the endothelial derived relaxing factor, NO importent? Because it causes upstream (large vessel) dilation.
How does high pressure effect the vessels? The vessels gets stretched -> less resistens.
Created by: Malekian
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