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Advanced Patho
Cells of Inflammation
Question | Answer |
---|---|
What are endothelial cells?` | Single-cell thick lining of blood vessels; they can produce antiplatelet and antithrombotic agents that help keep the vessel clear and open and they also are responsible for the constriction and dilation of said vessels |
What are platelets? | 1. Small membrane bound disks that circulate in the blood 2. Activated platelets also release strong inflammatory mediators which increases vascular permeability |
What are leukocytes? | 1. Major cellular components during inflammatory response |
What are the sub-cell types within the category of leukocytes? | 1. Granulocytes (neutrophils, eosinophils, basophils ) which contain cytoplasmic granules 2. Agranulocytes (monocytes/macrophages and lymphocytes) which do not have any granules |
Neutrophils make up what % of circulating WBC's? | 60-70% |
How fast are neutrophils in reacting to tissue damage? | They are the 1st to arrive on scene, usually arriving within 90 minutes |
How do neutrophils act when at the site of injury? | They act as scavengers, eating other bacteria and cellular debris via phagocytosis |
How long do neutrophils live in circulation? | They have a short life span, dying by apoptosis (cellular suicide) and disappear between 24-48 hours after entering the damaged site |
Eosinophils make up what % of circulating WBCs? | 2-3% |
How fast are eosinophils in reacting to tissue damage? | Usually arrive on scene 2-3 hours after neutrophils |
Eosinophils play an important role in this type of reaction | Allergic reactions because they control the release of specific chemical mediators |
Why would eosinophils present in chronic inflammation? | Because they have a longer life span that neutrophils do |