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Advanced Patho

Cells of Inflammation

What are endothelial cells?` Single-cell thick lining of blood vessels; they can produce antiplatelet and antithrombotic agents that help keep the vessel clear and open and they also are responsible for the constriction and dilation of said vessels
What are platelets? 1. Small membrane bound disks that circulate in the blood 2. Activated platelets also release strong inflammatory mediators which increases vascular permeability
What are leukocytes? 1. Major cellular components during inflammatory response
What are the sub-cell types within the category of leukocytes? 1. Granulocytes (neutrophils, eosinophils, basophils ) which contain cytoplasmic granules 2. Agranulocytes (monocytes/macrophages and lymphocytes) which do not have any granules
Neutrophils make up what % of circulating WBC's? 60-70%
How fast are neutrophils in reacting to tissue damage? They are the 1st to arrive on scene, usually arriving within 90 minutes
How do neutrophils act when at the site of injury? They act as scavengers, eating other bacteria and cellular debris via phagocytosis
How long do neutrophils live in circulation? They have a short life span, dying by apoptosis (cellular suicide) and disappear between 24-48 hours after entering the damaged site
Eosinophils make up what % of circulating WBCs? 2-3%
How fast are eosinophils in reacting to tissue damage? Usually arrive on scene 2-3 hours after neutrophils
Eosinophils play an important role in this type of reaction Allergic reactions because they control the release of specific chemical mediators
Why would eosinophils present in chronic inflammation? Because they have a longer life span that neutrophils do
Created by: colclesseral1