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Chapter 19

Blood traveling mobile unit with many functions Nutrients/Oxygen In, Wastes Out
5 blood functions *Transporter, oxygen delivery, CO2 out, protection, acid-base balance, hormones, and dissolves nutrients, & regulates body temperature
3 general characteristics 38C, 100.4 F( normal temp), high viscosity, & slightly alkaline pH(7.35-7.45)
Plasma (water & proteins), 55% of blood Water most component, albumin most protein Serum(fibrinogin clots)
Formed Elements (solids), 45% of blood, Erythrocytes, leukocytes, & platelets
Composition of Blood Plasma: water, albumin protein, nutrients, gases, hormones, & electrolytes Buffy Coat: WBC's & platelets Hematocrit: RBC's
Protein functions clotting, Immune system transporter, regulate fluid volume
Buffy Coat WBC (fight) & Platelets (patch) Beige color, & less than 1% of blood volume
Hematocrit heaviest so they sink to bottom during fractionation. 400 billion platelets, 200 billion RBC, & 20billion WBC (daily).
Blood Cell Formation Hemopoiesis: Red Bone Marrow-produce all types of blood cells. Ends of long and flat bones. Lymphatic Tissue- produce lymhocytes. Spleen, lymph nodes, and thymus gland.
Stem Cells in Red Bone Marrow Reticulocytes= Immature Thrombocytes= Platlet Never(60) Let(30) My(5) Engine(2) Blow(2)! Neutrophils, Lymphocytes, Monocytes, Eosinophils, & Basophils
Erythrocytes deliver oxygen, remove co2 blood has more RBC than any other formed element cytoskeleton=strechanle making it flexible, coming back to its shape.
RBC's Disc Shape, No Nucleus/DNA, lives 120 days
Hemoglobin 1/3 of RBC filled with hemoglobin-red color 4 proteins=globins, each gobin bound to iron molecule=heme, each heme can bound to one oxygen molecule. 1 hemoglobin can carry 4 oxygens
Normal Blood Hematocrit: F37-48%, M45-52% Hemoglobin: F12-16 g/dl, M13-18 g/dl RBC count: F4.2-5.4 million/mm, M4.6-6.2 million/mm Women lose more blood which lowers hematrocrit levels.
Iron Requirements Iron is oxyen carrier dietary iron is required for hemoglobin synthesis, 5-20 mg from food each day
Sickle Cell Disease Inheritate, stiff and inflexible, does not return to its shape No oxygen=pain
Created by: Asuzenam