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Fungal Infections

Infectious Disease

Fungal arthritis etiology often immunocompromised pts; chronic indolent course; endemic dimorphic fungi in gardeners / occupations w/exp to soil
Fungal arthritis: Candida: RFs surg procedures, joint injections, critical illness (knee, hip or shoulder); IVDUs: spine, SI joints
Fungal arthritis: non-candida agents: Aspergillus, Cryptococcus, Pseudallescheria, dematiaceous fungi
In patients with asthma or CF. Thick brown tenacious mucus plugs in sputum Allergic bronchopulmonary aspergillosis
Aspergilloma occurs when: Fungus colonizes existing cavitary pulmonary lesions. Often invades blood vessels and may present with hemoptysis
Disseminated aspergillosis sx/sx In immunocompromised pt. Pleuritic chest pain, cough, necrotic skin lesions, tissue infarction, wound infections, brain abscesses
Dimorphic fungus infecting men in water, by inhalation of mold from rotting wood & soil: Blastomycosis
Blastomyces is found where? SE, central, & midwest US
Common forms of Blastomycosis Pulmonary most common. Hematogenous usually bone, skin, GU
Verrucous, crusted, or ulcerated skin lesions leave a central scar with healing in: Blastomycosis
Coccidioides pathology Inhalation of highly infectious athroconida (hyphae of the mold form). Common opportunist in HIV patients
Coccidiomycosis clinical features Resp sxs, pulmonary cavitations & abscesses. pain/swelling of knees & ankles, erythema nodosum.
People most often affected by Coccidiomycosis / disseminated infection: African Americans, Filipinos, PG women
Respiratory infection from pigeon & other bird droppings in immunocompromised patients Cryptococcus
Cryptococcus clinical features HA first sx of meninoencephalitis; papilledema. Resp infxns often asymptomatic. 95% of HIV patients are positive
Dimorphic fungus in soil contaminated with bat/bird droppings in Ohio & Mississippi River valleys Histoplasmosis
Histoplasmosis clinical features Resembles flu. Acute dz 9often epidemic): 1-6 weeks, fever & prostration.
Diffuse PNA on CXR with few pulmonary symptoms = Histoplasmosis
Progressive disseminated histoplasmosis clinical features: Involves all organs & is usually fatal. Fever, SOB, wt loss, HSM, bloody diarrhea.
Chronic progressive pulmonary histoplasmosis occurs in: Older patients with COPD
Dermatophytosis organisms Trichophyton, Microsporum, Epidermophyton spp; most common = Trichophyton rubrum
Created by: Abarnard