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Drug Products Final
| Question | Answer |
|---|---|
| Drugs must be in what form to pass membranes and get access to bodily fluids? | free form |
| Drugs will be more concentrated where they are _______. | ionized |
| Acidic Drugs are more concentrated in _______. | plasma |
| Basic drugs are more concentrated in ________. | milk |
| what percentage of the mother's drug dose ends up in mother's breast milk? | <5% |
| CYP3A4 and CYP2C9 do not reach full glucuronide conjugation capabilities until what age? | 6 months to a year |
| The rate of increase in drug concentration with time in the dissolution medium. | Drug Dissolution Rate |
| D = ____________. (Noyes Whitney Equation) | diffusion coefficient |
| S= _____________. | surface area |
| Cs= maximum ______________ of the drug in the saturated layer | solubility |
| C= ________________ of the drug in bulk solution | concentration |
| Cs-C= __________ ______________ between the diffusion layer and the bulk solution | concentration gradient |
| H=___________. | thickness |
| The driving force for dissolution is the _________ __________ between the diffusion layer and the bulk solution. | concentration gradient |
| In the "Cs-C" part of the NW equation, we can ignore the "____" term due to the fact that our body is an _______ _______. | infinite sink |
| The dissolution of solid into the medium. | Kdis |
| The absorption of the drug from the solution across the membrane | Kabs |
| Either the Kdis or the Kabs can be ________ _________. | rate limiting |
| drugs with _____________ water solubility tend to show membrane rate limited absorption | increased. |
| Concerning drugs with increased water solubility, the rate of dissolution is _______ than the rate of absorption | greater |
| drugs that are increasingly water soluble tend to cause ________ __________ due to large amounts of drug in solution at the membrane. | GI irritation |
| drugs with ___________ water solubility, tend to show dissolution rate limited absorption. (Kdis > Kabs) | decreased |
| Concerning drugs with decreased water solubility, the rate of dissolution is __________ than the rate of absorption. | less |
| For drugs that are __________, dissolution may be helpful in providing bioavailability. | DRLA |
| USP has several official methods for testing _________ dissolution | in vitro |
| __________ __________ method: sometimes criticized due to the fact the tablet is bouncing around inside the cage. | rotating basket |
| ____________ method ( one of the most popular methods for testing in vitro dissolution) | paddle |
| The faster the drug is dissolves, the higher the _________. | AUC |
| AUC and dissolution correlate for ___________ drugs. | DRLA |
| the better the dissolution, the ________ the extent of absorption. | higher |
| dissolution and ____________ may NOT be correlated. | disintegration |
| disintegration only shows how well the drug ________ ______, not if it goes into solution | breaks up |
| dissolution rates of ___________ formulations of a drug differ from that of the parent compound. | salt |
| salt form of a ______ ________ may also improve its pharmacological action. | weak acid |
| different salt forms change the dissolution of the drug at different ______. | rates |
| salt forms are sometimes undesirable when: the salt form has a lower _______________ than the free acid form. | bioavailability. |
| salt forms are sometimes undesirable when: _______ onset is NOT desired. | rapid |
| salt forms are sometimes undesirable when: the drug is _________ at low pH environments | unstable |
| _______________ is an example of an acid labile drug. | erythromycin |
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