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Pharma I
Pharma antibiotics I facts from lecture
Question | Answer |
---|---|
What is CCT? | Cancer chemotherapy. Therapy that distinguishes based on differences between normal and neoplastic. Treatment nonselective. |
What is ACT? | Exploit differences between pathogenic organism and host. |
What are the ways mechanisms of ACT? | 1)Inhibit cell wall synth 2)Alter cell wall perm 3)Inhibit protein synthesis 4)Inhibit nucleic acid synthesis 5)antimetabolite |
What is the log kill concept? | Each regin of CT kills constant %. ACT has much lower log kill than CCT. |
What is the bacteriostatic? What is MIC? | Inhibit growth of bacteria. MIC - Minimal inhibitory concentration. |
What is bacteriocidal? What is MBC? | Kill bacteria. MBC - Minimal bactericidal Conc. Usually MIC measured. |
What is the postantibiotic effect? (PAE) | PAE = T(time required for viable count to increase 10 times above count immediately before drug removed) - C (Time required for count in an untreated culture to increase 10 times above the count |
What are antibiograms? | The result of a lab testing for sensitivity of an isolated bacterial strain to antibiotics. |
What are the pharmacodynamic adverse effects of ABS?q | Ototoxicity, nephortoxicity |
What are the allergic SEs of penicillin? | Rash |
Can a superinfection result from antibiotics? | Yes, C. Diff |