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Chapter 17

Blood - The clotting process, disorders of Hemostasis

hemostasis: stops the bleeding
when blood clots, it plugs holes in ___ to ___ blood vessels - stop leaking
what are the 3 stages of hemostasis? vascular spasm, platelet plug formation & coagulation
what happens during the vascular spasm? the smooth muscle contracts - which slows bleeding
in platelet plug formation: formed elements activates damaged tissue that make platelets sticky- forms plug that temporally seals vessel break
the collagen gets exposed in what step of hemostasis? platelet plug formation
in coagulation, what happens? fibrin forms a mesh that acts as a molecular glue - > traps RBC's & platelets -> clot forms
what protein is involved in final step of clotting? thrombin
plasma proteins are produced by the: liver
in coagulation, intrinsic means: found in the blood
in coagulation, extrinsic means: comes from outside from other tissues
the prothrombin activator is made in __ and requires ___ intrinsic - calcium
when is thrombin activated? in the extrinsic process
what enzyme converts fibrinogen to fibrin? thrombin
after thrombin clings to fibrinogen, what is produced? a cross-linked fibrin mesh
what dissolves the clot? TPA
what are anticoagulants? helps balance the clotting factors
low-dose aspirin, heparin, and warfarin are all examples of: anticoagulants
fibrinolysis gets rid of __ the clot when tissue is healing
heparin inhibits __ vitamin K
what enzyme digests fibrin? plasmin
endothelial cells around clot secretes __ that converts __ to __ TPA -> plasminogen -> plasmin
__ and __ also activates plasmiogen activator 12 & thrombin
a clot that develops & persists when there is no clot in the vessel is called a__ thombus
a thombus may be broken free & floats through the blood vessel embolus
what is an embolism? an embolus that's stuck & obstructing a blood vessel
thrombocytopmeia means: you don't have enough platelets
if factor __ and __ is missing, you will have a problem with clotting 11 & 12
what is required for clotting factor production by the liver? vitamin K
an __ is anything that can make an antibody antigen
the number of disorders caused by deficiences in the blood factor is called: hemophilia
bleeding disorders arise from: interfering with clotting
what blood type is the universal donor? O
what blood type is the universal recipient? AB
blood type AB has: no antibodies & AB antigens
blood type A has: A antigens & Anti-B antibodies
blood type B has: B antigens & Anti-A antibodies
blood type O is composed of: no antigens & Anti-A & Anti-B antibodies
blood that can be received by blood type AB A, B, AB, & O
blood that can be received by blood type B B,O
blood that can be received by blood type A A,O
blood that can be received by blood type O O
what is free hemoglobin toxic to? kidneys
what can happen if you get the wrong type of blood? fever allergic reaction hemolysis lung problems
transfusion reactions can be __ or __ due to: acute or delayed - antibody reaction to donor cells
Created by: Mariahj25