Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Derm Systemic 1
Derm
| Question | Answer |
|---|---|
| Autoimmune disorders with cutaneous signs | SLE, dermatomyositis, scleroderma, vasculitides |
| endocrine disorders with cutaneous signs | diabetes |
| immune disorders with cutaneous signs | dermatitis herpetiformis, urticaria/angioedema, sarcoidosis |
| metabolic disorders with cutaneous signs | xanthelasma |
| >__% of patients with SLE have skin findings | 85 |
| subset of patients with __ have cutaneous, but not systemic disease | lupus erythematosus |
| 3 categories of skin manifestations of SLE | acute cutaneous, subacute cutaneous, chronic cutaneous (discoid lupus) |
| aka discoid lupus | chronic cutaneous lupus |
| other dermatologic manifestations of SLE | alopecia and oral ulcers |
| __ is very common in those with lupus, sun exposure may trigger acute lesions | photosensitivity |
| localized or generalized face, scalp, upper extremities (malar or butterfly rash), papules, papular urticaria, scaly plaques, discoid lesions, bullae, palmar erythema | acute cutaneous LE (ACLE) |
| scaly plaques are more commonly associated with __LE | subacute cutaneous LE |
| discoid lesions are more commonly associated with __ LE | chronic cutaneous LE |
| __% of patients with SCLE have SLE | 50 |
| typically start as small erythematous papules with scale, associated with anti-Ro and anti-La antibodies, | annular or papular (psoriaform) lesions associated with SCLE |
| __% of SLE patients have discoid lesions | 25 |
| non-specific lesions/rashes associated with SLE | lupus profundus (lupus panniculitis), vasculitic lesions (purpura), livedo reticularis, urticaria |
| one of the idiopathic inflammatory myopathies; heliotrope is classic cutaneous lesion | Dermatomyosistis |
| considered pathognomonic of dermatomyositis | Gottron's papules |
| slightly raised pink, dusky red or violaceous papules over the dorsal sides of the MCP/PIP and or DIP joints, can occur over wrists elbows or knees (pathognomonic for dermatomyositis) | Gottron's papules |
| macular rash over posterior shoulders/neck. seen in dermatomyositis | shawl sign |
| macular photosensitivity rash over anterior neck, can aslo occur on face or scalp. associated with dermatomyositis | V sign |
| nail findings of dermatomyositis | periungual erythema, telangiectasias, cuticle overgrowth |
| systemic sclerosis | scleroderma |
| localized scleroderma | morphea, linear scleroderma |
| localized plaques or linear, band-like distribution, most common in women, peak age of onset 20-50, rarely progresses to systemic disease | localized scleroderma |
| sclerodactyly, Raynaud's phenom, sclerosis of face, scalp, trunk, periungual and mat-like telangiectasia, pigmentation abnormalities, calcinosis cutis | systemic scleroderma |
| erythematous or violaceous macular rash of eyelides, peri-orbital area, often accompanied by edema; DM | Heliotrope |
| scleroderma epidemiology | F>M; 20-50 yrs |
| systemic,immunologic,genetic disease manifesting in skin and/or joints | psoriasis |
| psoriasis lesions: | Red scaling papules coalesce to round-oval plaques |
| psoriasis epidemiology | 2.1% of US adults (4.5M); 1M psoriatic arthritis; 200K new cases/yr |
| Psoriasis most common sites | scalp, elbows, legs, knees |
| Psoriasis common findings | Chronic plaque; Erythroderma; Pustular; Guttate; Intertriginous |
| Most common type of psoriasis | plaque psoriasis: erythematous oval plaques, distinct borders, w/silver-white scale |
| Drugs that exacerbate psoriasis | Lithium; Beta-blockers; Antimalarials; Systemic steroids |
| Factors that flare psoriasis: | Strep infxn; Injury or trauma; Drugs; Low humidity; Emotional stress; Overtreatment |
| Guttate psoriasis | Small papules of short duration (weeks to months); Usually children and young adults; often after strep |
| Most common type of psoriatic arthritis | asymmetrical arthritis |
| Psoriasis etiology | T-cell-mediated hyperproliferation of epidermis -> inflammation of epidermis / dermis -> keratinocyte hyperproliferation |
| Psoriasis: associated conditions | CVD, depression, lymphoma |
| Silvery scaling plaques on extensor sensors. Ausptiz sign, Koebner phenomena; sausage fingers | Psoriasis |
| Rat bite erosions on X-ray | Psoriatic arthritis |
| Psoriasis: 5 variants = | plaque, pustular, guttate, inverse, erythrodermoid |
| psoriasis tx | topical steroids & vit D; coal tar / ASA preps; topical retinoid prn; for severe: cyclosporine, MTX, PUVA |
| von Zombusch syndrome | pustular psoriasis: emergency; diffuse pustules coalesce => lakes of pus; fever, malaise, high WBC |
| erythrodermoid psoriasis = | generalized, over most of skin; hypermetabolic state requiring hospitalization |
| psoriasis mgmt | Acitretin (0.5mg/kg; teratogen) vs MTX / Csteroid vs retinoids. |
| psoriasis tx categories | Topical (tar & CS, vit D & A/retinoid); phototherapy (UVB); MTX; cyclosporin A; Biologics (alefacept / efalizumab) |
| pemphigus vulgaris etiology | bullous autoimmune dz; IgG Ab => acantholysis => loss of cell-cell adhesion |
| pemphigus vulgaris S/S | oral mucosa lesions precede skin by 6-12 mos; pain (no itch); Nikolsky sx |
| pemphigus vulgaris tx | systemic tx: prednisone + immunosuppressives, azathioprine +/- MTX |
| Pemphigus may be side effect of what med class? | ACEI |
Created by:
Abarnard
Popular Medical sets