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cell 2 cell junction that form mechanical n electrical connections between all cardiac contractile n conduction cells r called gap junctions
myocyte/contractile cell membrane is called sarcolima
filled with extracellular fluid and has extensions of plasma membrane penetrate into the cell n r open to the extracellular space t-tubules
the t-tubules allow 4 the movement of large amounts of------into the cell where it moves into the sarcoplasmic reticulum calcium
endoplasmic reticulum is called sarcoplasmic reticulum
sarcoplasmic reticulum store ---------- obtained from the t-tubules calcium
myosin, actin, troponin, tropomyocin 3 contractile/motor proteins in the contractile cell
myosin is referred to as a --------- protein with small projections called bridges or ===== thick, heads
thin, double actin is referred to as ====== protein arranged in a ===== strand
actin proteins contain binding sites 4 myosin heads
actin also includes the proteins tropomyocin and troponin complex
there are 3 parts to troponin troponin I,T, and C
troponin C portion of the complex interacts with calcium
located n the groove between the 2 actin strands and covers the myosin binding sites on the actin tropomyocin
sarcomere a contractile unit of the actin n myosin proteins
a conduction cell generates an action potential
the conduction cell === and causes=== gated sodium and calcium channels in the ===== to open depolarizes, voltage, and gap junctions
sodium and calcium moves into the contractile cells
na+ and ca++ causes the charge in the cell to become more==== and changes the ==== positive, membrane potential
the change in membrane potential causes==== channels to open and tons of na+ moves into cell voltage gated fast sodium
when na+ moves into cell membrane to on the action potential wave depolarizes, also called phase 0
during phase 0, k+ channels are closed
tons of sodium move in the inside of the inner cell membrane become ---- and referred to as positive, "overshoot" or phase 1
positive charge in "overshoot" causes======= to open and ==== starts moving into contractile cells from ====== voltage gated slow calcium calcium extracelluar fluid
phase 2 on the action potential wave is called plateau
the calcium moving into the cell during the plateau phase causes a voltage change inside the cell. causes voltage gated calcium channel in the sarcoplasmic reticulum to open and tons of calcium moves in the sarcoplasm
calcium binds to======which changes its shape/conformation troponin c
the shape change rolls ==== off the myosin binding active sites on the==== tropomyocin, actin
=== hydrolysis causes the myosin heads to change their shape. they move onto the myosin binding sites on the ====, this process is called=== ATP, actin bridging
as long as === and == are present the cross bridging continues atp ca++
the myosin heads shift and move the actin forward
in relaxation ===and binds to the myosin heads and they detach from the ===;everything moves back to its original position to get ready for the next contraction atp actin
which type of calcium movement creates the electrical currents in the cardiac myocyte calcium movement across the sarcolemma
calcium movement out of the sarcoplasmic reticulum occurs by diffusion, from higher to lesser concentration
calcium moves back into the sarcoplasmic reticulum by active transport, lesser to higher concentration
calcium moves back into the sarcoplasmic reticulum during diastole
Created by: t4achange