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Toews - Exam2

Eicosanoids and related compounds

eicosanoids are 20 carbon derivatives of arachindonic acid, they include prostaglandins, thromboxanes, and leukotrienes
arachidonic acid 20:4 omega 6 fatty acid, must be obtained from diet or synthesized from linoleic acid (18:2 omega 6)
prostaglandins (blank)
thromboxanes (blank)
leukotrienes (blank)
phospholipase A2 (PLA2) enzyme that cleaves arachidonic acid from phospholipids in the plasma membrane for eicosanoid synthesis
cyclooxygenase (COX-1 and COX-2) enzyme that converts arachidonic acid to prostaglandins and thromboxanes, COX-1 is constituitive in most cells--> many effects, COX-2 is inducible in macrophages--> inflamatory response and other effects
lipoxygenase converts arachidonic acid to leukotrienes-->important for bronchial constriction
anti-inflammatory steroids inhibit PLA2
NSAIDS non-steroidal antiinflammatory drugs inhibit COX-1 and COX-2
COX-2 inhibitors treat inflammation by blocking COX-2 --> benefit of NSAIDS without stomach complications
Created by: MouserKat