Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
WVSOM immuno #4
WVSOM immune system #4 immuno
| Question | Answer |
|---|---|
| What are the organs of the immune system? | thymus, bone marrow, spleen, lymphnode, other lymphoid tissue |
| What are the cells of the immune system? | lymphocytes, antigen-presenting cells, inflammatory cells |
| What are the soluble factors of the immune system? | Antibody, cytokines, complement |
| What is the cell surface proteins? | MHC proteins, cell adhesion molecules, receptors, CD proteins (e.g,CD4, CD8) |
| What is the major role of Primary immune organ? | place where phagocytes, Maturation production |
| What are some primary lymphoid organs? | thymus, bone marrow |
| What are the secondary lymphoid organs and tissues? | tonsils and adenoids, bronchus associated lymph tissue, lymph nodes, bone marrow, spleen, lymphoid nodules, mesenteric lymph nodes, peyer’s patch, urogenital lymphoid tissue |
| Does each factor active the same transcription factor causing similar responses? | NO, Different factors activate different transcription factors causing different responses |
| What two types of progenetor cells does a pluripotent stem cell make? | lymphoid and myeloid |
| What does the lymphoid progenitor differentiate into? | B and T lymphocytes and natural killer cells |
| What does Myeloid progenitor cells differentiate into? | Erythroid CFU, Megakaryocyte, Basophile CFU, Eosinophil CFU, and granulocyte-monocyte CFU |
| What does Erythroid CFU differentiate into? | erythrocytes |
| What does Megakaryocytes make? | platelets |
| What does Granulocytes make? | neutrophils |
| Where is the primary site for B lymphocyte development and hematopoesis? | Bone marrow |
| The growth factor stem cell factor (SCF) affects what cells? | All hematopoietic cells |
| The growth factor IL-3 (multi-CSF) affects what cells? | Granulocytes, monocytes, RBC |
| The growth factor GM-CSF affects what cells? | granullocytes, monocytes, dendritic cells |
| The growth factor G-CSF affects what cells? | neutrophils (PMN) |
| The growth factor Erythropoietin affects what cells? | Erythrocytes |
| What is the Primary purpose of the thymus gland? | maturation and education of T cells |
| What is happening In the Education process of the thymus gland? | tells them to develop and eliminate the T-cells that may be auto-reactive so they won’t attack us, Make sure that the T cell only recognize the antigen |
| Explain the adult thymus: | You will still find some activity in the adult thymus but for the most part there is a lot of atrophy |
| Is the spleen a primary or secondary lymphoid organ? | secondary |
| What do lymphoid cells in the white pulp of the spleen surround? | arteries |
| Spleen what does it do? | Primary function is to filter blood and sample the blood for pathogens and present antigens |
| What is the purpose of lymphoid tissue? | will sample the organisms that may be in the blood to determine the response, sample and induce immune response |
| What is the major complication for spleenectomy? | infections |
| Is the spleen important in fighting infection? | very important as anti infection mechanism |
| What are the Collection points among the lymphatic organs? | tonsils, thymus, lymph nodes, lymphatic vessels, liver, spleen, peyer’s patch on small intestine, appendix, and bone marrow |
| Where is the lymph is filtered and sampled for pathogens? | lymph nodes |
| Is the lymph node an Antigen presenting cells as well? | yes |
| What type of cells are primarily in the Cortex of the lymph node? | B cell cells |
| Under the cortex is the paracortex in the lymph node is where most of the what hang out? | T cells hang out and antigen presenting cells |
| Under the paracortex of the lymph node you find the medulla area where what happens? | lymph will come in and exit the lymph node |
| Are the areas of the lymph node physically separated? | no they interact with each other so the B cells and T cells need to inter act to activate each other. |
| What does the primary follicles look like in the lymph node? | Primary are quiet not been activated and they stain dark |
| What does the Secondary follicles look like in the lymph node? | have a lot more going on they stain lighter |
| Where do you find Mucosa-associated lymphoid tissues (MALT)? | Anywhere you will have an opening you have mucous membrane and you have lymphoid tissue, eg. Respiratory, GI, urogenital |
| What is the function of the appendix? | You really don’t know the function of the appendix but seems to be responding to antigens because they have a lot of lymphoid cells in it |
| What do B lymphocytes differentiate into? | plasma cells that make antibody |
| What are T cells? | the regulators of the immune system they have helper and killer function |
| What are the two major classes of lymphocytes? | B and T lymphocytes |
| Natural killer cells are not antigen specific but they are another form of what? | lymphocytes the major function is to kill virus infected cells and tumor cells |
| What is the function of natural killer T cell (NKT)? | recognize glycolipids |
| What are Antigen presenting cells? | cells that present antigen |
| Does T-cells have to have antigenic peptides presented before they are activated? | yes |
| Lymphocytes of the immune system have to recognize antigen on the surface of the cell before what can happen? | activation of the immune response |
| Will T lymphocyte recognize some antigen on its own surface? | No only on the surface of another cell |
| What is included in APC? | dendritic cells, macrophages, and B-lymphocytes |
| What is the important purpose of dendritic cells? | its the most important APC for activating T cells |
| List some inflammatory cells? | neutrophils, eosiniophils, basophils, mast cells, epithelial cells, endothelial cells, platelets |
| What are cell surface molecules? | cell adhesion molecules, membrane receptors, major histocompatibility complex (MHC) proteins, and CD molecules |
| How many different types of receptors are there? | one for every type of cell, one for B,T,ect. |
| When was MHC proteins first discovered? | when they started doing organ transplants, the host body would reject the donor organ due to the difference in MHC proteins |
| Why does MHC activate the immune response? | These are involved in activating the t cells, they differ from person to person, MHC proteins have a little pocket with proteins in it that the T cells recognize, this will activate the immune response |
| Where is CD2 expressed and what is its function? | T cells, NK; adhesion |
| Where is CD3 expressed and what is its function? | T cells; activation |
| Where is CD4 expressed and what is its function? | helper T cells; adhesion |
| Where is CD8 expressed and what is its function? | killer T cells; activation |
| Where is CD21 expressed and what is its function? | B cells; activation |
| Where is CD34 expressed and what is its function? | stem cells; adhesion |
| Where is CD40 expressed and what is its function? | B cells; activation |
| Where is CD95 expressed and what is its function? | many cells; apoptosis |
| Are there many cytokines and What are cytokines? | Many different types of cytokines they are the communication molecules that induce stuff on other cells |
| List some soluble immunologic factors: | immunoglobulin (antibody), complement, cytokines |
| What produces antibodies and what is their function? | immunoglobulins are produced by plasma cells and they mediate antigen recognition and immune effector functions |
| What are the functions of the immune effector? | antigen binding, neutralization of microbial toxins, inhibiting attachment of microbes, opsonization, activate complement, and protection of developing fetus |
Created by:
hagerman
Popular Medical sets