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cholesterol syn
Stack #21721
Question | Answer |
---|---|
VLDL | synthesized by the liver, digested by lipoprotein lipase in peripheral tissue, converted to IDL |
IDL | endocytosed in liver and degraded by lysosomal enzymes |
assembly of chylomicons | Tag's assembled in smooth er and use Apo B48 from th rough ER, aquire Apo E and Apo C2 from HDl |
Bile salts | Cholesterol gets and alpha-hydroxyl group at carbon 7, further oxidized to chenocnolic or cholic acid, conjucated with glycine or taurine |
cholesterol synthesis | acetyl CoA-mevalonate-isoprene units-squalene-cholesterol |
rate limiting step in cholesterol synthesis | HMG CoA reductase |
rate limiting step in bile salt synthesis | 7 alpha hydroxylase |
HDL | synthesized by liver, major protien is ApoA, trasfers ApoC2 and ApoE to VLDL and chylomicrons |
Apo CII | activates lipoprotien lipase |
Apo E | recognition factor for cell surface receptor |
LDL | endocytosed by peripheral tissues, cholesterol inhibits synthesis of receptors |