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cholesterol syn

Stack #21721

QuestionAnswer
VLDL synthesized by the liver, digested by lipoprotein lipase in peripheral tissue, converted to IDL
IDL endocytosed in liver and degraded by lysosomal enzymes
assembly of chylomicons Tag's assembled in smooth er and use Apo B48 from th rough ER, aquire Apo E and Apo C2 from HDl
Bile salts Cholesterol gets and alpha-hydroxyl group at carbon 7, further oxidized to chenocnolic or cholic acid, conjucated with glycine or taurine
cholesterol synthesis acetyl CoA-mevalonate-isoprene units-squalene-cholesterol
rate limiting step in cholesterol synthesis HMG CoA reductase
rate limiting step in bile salt synthesis 7 alpha hydroxylase
HDL synthesized by liver, major protien is ApoA, trasfers ApoC2 and ApoE to VLDL and chylomicrons
Apo CII activates lipoprotien lipase
Apo E recognition factor for cell surface receptor
LDL endocytosed by peripheral tissues, cholesterol inhibits synthesis of receptors
Created by: swohlers
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