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Enzymes 1


Synthesizes the active tetrahydrofolate (THF) form of folic acid. Dihydrofolate reductase
Makes a phosphodiester bond between adjacent nucleotides in DNA DNA ligase
Adds TTAGGG sequences to the ends of chromosomes Telomerase
Synthesizes deoxy form of nucleotides Ribonucleotide reductase
Salvages guanine bases to make GMP HPRT
Catalyzes formation of uric acid Xanthine oxidase
Has a MG++ cofactor that funcitons to enhance nucleophilic attack by the 3'O of the primer strand DNA polymerase
Synthesizes an RNA primer to initiate strand synthesis Primase
Separates the parental strands at the replication fork Helicase
The biochemical function of cAMP is to activate _______________. Protein kinase A
An enzyme that digests DNA at specific base sequences.
Inhibited by malathion Acetylcholinesterase
Catalyzes the first step in glycolysiss that produces ATP by substrate-level phosphorylation Phosphoglycerate kinase
Has a high Km for glucose and is acive after a meal Glucokinase
Covalently links amino acids to their cognate tRNAs Aminoacyl-tRNA synthetase
Synthesizes cDNA from mRNA resverse transcriptase
Synthesizes RNA RNA polymerase
The enzyme primarily responsible for metabolizing alcohol Alcohol dehydrogenase
Stimulates the activity of phosphofructokinase-1 (PFK-1) Fructose 2,6-bisphosphate
Catalyzes the production of NADH in glycolysis Glyceraldehyde 3-P dehydrogenase (GAPDH)
Major regulated step of cholesterol biosynthesis HMGCoA reductase
Enzyme in eukaryotes that is responsible for mRNA transcription
Pyruvate carboxylase enzyme requires ___________. Biotin
Catalyzes the first enzymatic step of steroid synthesis Desmolase
Pyruvate dehydrogenase requires this as a cofactor. thiamin-pyrophosphate
Homocysteine methyltransferase requires this as a cofactor Cobalamin (B12)
Recognizes oriC and recruits the replication proteins E. coli DnaA
Seals the nick in the phosphodiester backbone DNA ligase
Introduces negative supercoils in the DNA DNA gyrase
Synthesizes the bulk of human DNA DNA polymerase delta
Functions as a "sliding clamp" to make polymerase processive PCNA
Inhibited by methotrexate Dihydrofolate reductase
Inhibited by ciprofloxacin DNA gyrase
Inhibited by azaserine Carbamoyl phosphate synthetase II
Inhibited by allopurinol Xanthine oxidase
Inhibited by fluorouracil Thymidylate synthase
First step in the metabolism of alcohol Alcohol dehydrogenase
Cleaves the signal peptide from the N-terminus of the growing polypeptide Signal peptidase
Breaks and reforms S-S bonds between cystein residues in protein folding Protein disulfide isomerase (PDI)
Shifts proline configuratin between cis and trans isomers Peptidyl proline isomerase (PPI)
Allows proteins containing proline to adopt the correct configuration Peptidyl proline isomerase (PPI)
Phosphorylates translational initiation factors (Ifs)leading to the inhibition of translation and reduces proteins entering the ER Protein ER Kinase (PERK)
A complex of E2/E3 which recognizes and tags a damaged protein for destruction. Ubiquitin ligase
Enzyme that cleaves fatty acids from phsopholipids. Phospholipases
Hydrolyzes the ester on the C1 carbon of a phospholipid, giving a free fatty acid and a 1-lysophospholipid Phospholipase A1
Hydrolyzes the ester on the C2 carbon of a phospholipid, giving a free fatty acid and a 2-lysophospholipid Phospholipase A2
Hydrolyzes the phosphoester bond between the phosphate and the glycerol backbone giving DAG and phosphorylated head group in a phospholipid Phospholipase C
Hydrolyzes the phosphoester bond between the phosphate and the head group giving PA and free head group in a phospholipid Phospholipase D
Synthesizes cAMP Adenylyl cyclase
Breaks down cAMP Phosphodiesterase
Created by: P1StudyStack
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