Enzymes 1 Word Scramble
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| Question | Answer |
| Synthesizes the active tetrahydrofolate (THF) form of folic acid. | Dihydrofolate reductase |
| Makes a phosphodiester bond between adjacent nucleotides in DNA | DNA ligase |
| Adds TTAGGG sequences to the ends of chromosomes | Telomerase |
| Synthesizes deoxy form of nucleotides | Ribonucleotide reductase |
| Salvages guanine bases to make GMP | HPRT |
| Catalyzes formation of uric acid | Xanthine oxidase |
| Has a MG++ cofactor that funcitons to enhance nucleophilic attack by the 3'O of the primer strand | DNA polymerase |
| Synthesizes an RNA primer to initiate strand synthesis | Primase |
| Separates the parental strands at the replication fork | Helicase |
| The biochemical function of cAMP is to activate _______________. | Protein kinase A |
| An enzyme that digests DNA at specific base sequences. | |
| Inhibited by malathion | Acetylcholinesterase |
| Catalyzes the first step in glycolysiss that produces ATP by substrate-level phosphorylation | Phosphoglycerate kinase |
| Has a high Km for glucose and is acive after a meal | Glucokinase |
| Covalently links amino acids to their cognate tRNAs | Aminoacyl-tRNA synthetase |
| Synthesizes cDNA from mRNA | resverse transcriptase |
| Synthesizes RNA | RNA polymerase |
| The enzyme primarily responsible for metabolizing alcohol | Alcohol dehydrogenase |
| Stimulates the activity of phosphofructokinase-1 (PFK-1) | Fructose 2,6-bisphosphate |
| Catalyzes the production of NADH in glycolysis | Glyceraldehyde 3-P dehydrogenase (GAPDH) |
| Major regulated step of cholesterol biosynthesis | HMGCoA reductase |
| Enzyme in eukaryotes that is responsible for mRNA transcription | |
| Pyruvate carboxylase enzyme requires ___________. | Biotin |
| Catalyzes the first enzymatic step of steroid synthesis | Desmolase |
| Pyruvate dehydrogenase requires this as a cofactor. | thiamin-pyrophosphate |
| Homocysteine methyltransferase requires this as a cofactor | Cobalamin (B12) |
| Recognizes oriC and recruits the replication proteins | E. coli DnaA |
| Seals the nick in the phosphodiester backbone | DNA ligase |
| Introduces negative supercoils in the DNA | DNA gyrase |
| Synthesizes the bulk of human DNA | DNA polymerase delta |
| Functions as a "sliding clamp" to make polymerase processive | PCNA |
| Inhibited by methotrexate | Dihydrofolate reductase |
| Inhibited by ciprofloxacin | DNA gyrase |
| Inhibited by azaserine | Carbamoyl phosphate synthetase II |
| Inhibited by allopurinol | Xanthine oxidase |
| Inhibited by fluorouracil | Thymidylate synthase |
| First step in the metabolism of alcohol | Alcohol dehydrogenase |
| Cleaves the signal peptide from the N-terminus of the growing polypeptide | Signal peptidase |
| Breaks and reforms S-S bonds between cystein residues in protein folding | Protein disulfide isomerase (PDI) |
| Shifts proline configuratin between cis and trans isomers | Peptidyl proline isomerase (PPI) |
| Allows proteins containing proline to adopt the correct configuration | Peptidyl proline isomerase (PPI) |
| Phosphorylates translational initiation factors (Ifs)leading to the inhibition of translation and reduces proteins entering the ER | Protein ER Kinase (PERK) |
| A complex of E2/E3 which recognizes and tags a damaged protein for destruction. | Ubiquitin ligase |
| Enzyme that cleaves fatty acids from phsopholipids. | Phospholipases |
| Hydrolyzes the ester on the C1 carbon of a phospholipid, giving a free fatty acid and a 1-lysophospholipid | Phospholipase A1 |
| Hydrolyzes the ester on the C2 carbon of a phospholipid, giving a free fatty acid and a 2-lysophospholipid | Phospholipase A2 |
| Hydrolyzes the phosphoester bond between the phosphate and the glycerol backbone giving DAG and phosphorylated head group in a phospholipid | Phospholipase C |
| Hydrolyzes the phosphoester bond between the phosphate and the head group giving PA and free head group in a phospholipid | Phospholipase D |
| Synthesizes cAMP | Adenylyl cyclase |
| Breaks down cAMP | Phosphodiesterase |
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