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BIOL 2402 CHP.19/18
BIOL 2402 CHP.19
Term | Definition |
---|---|
ABO Blood Group | Blood-type classification based on the presence or absence of A and B glycoprotiens on the erythrocyte membrane surface. |
Agglutination | Clustering of cells into masses linked by antibodies |
Agranular Leukocytes | Leukocytes with few granules in their cytoplasm EX: Monocytes ,Lymphocytes |
Albumin | 54%, osmotic pressure of blood along w/ Na+ blood buffer |
Anemia | Deficiency of red blood cells or hemoglobin |
Antibodies | (Immunoglobins or Gamma Globulins) antigen-specific protiens produced by specialized B lymphocytes that protect the body by binding to foreign objects such as bacteria and viruses |
Anticoagulant | substance such as heparin that opposes coagulation |
antithrombin | anticogulant that inactivates facator X and opposes the conversion of prothrombin (factor II) into thrombin in the common pathway |
B Lymphocytes | (B Cells) lymphocyes that defend the body against specific pathogens and thereby provide specfic immunity |
Basophils | WBC; less that 0.5-1% in blood; Has Granules(deep blue); Release chemicals that medicate inflammation and allergic respones |
Bilirubin | Yellowish bile pigment produced when iron removed from heme and is further broken down into waste products |
Biliverdin | Green bile pigment produced when the non-iron portion of heme is degraded into a waste product; converted to bilirubin in the liver |
Blood | Liquid connective tissue composed of formed elements - erythocytes, leukocytes, and platelets - and a fluid extracellular matrix called plasma; component of the cardiovascular system |
Bone Marrow Biopsy | Diagnostic test of a sample of red bone marrow |
Bone Marrow Transplant | Treeatment in which a donor's healthy bone marrow with its stem cells replaces diseased or damages bone marrow of a patient |
Buffy Coat | Thin,pale layer of leukocytes and platelets that separates the erythrocytes from the plasma in a sample of centrifu |
Carbaminohemoglobin | Compound of carbon dioxide and hemobglobin, and one of the ways in which carbon dioxide is carried in the blood |
Clotting Factors | Group of 12 identified substances active in coagulation |
Coagulation | Formation of a blood clot; part of the process of hemostasis |
Colony-Stimulating Factors(CSFs) | Glycoproteins that trigger the proliferation and differenation of myeloblasts into grammer leukocytes EX: Basophils, Neutrophils, and Eosinophils |
Common Pathway | Final Coagulation pathway activated either by the intrinsic or the extrinsic pathway, and ending in the formation of a blood clot |
Cross Matching | Blood test for for identification of blood type using antibodies and small samples of blood |
Cytokines | Class of proteins that act as autocrine or paracrine signaling molcules; in the cardiovascular system, they stimulate the proliferation of progenitor cells and help to stimulate both nonspecific and specifc resistance to disease |
Defensins | Antimicrobial proteins released from neutrophils and macrophages that create openings in the plasma membranes to kill cells |
Deoxyhemoglobin | Molecule of hemoglobin w/o an oxygen molecule bound to it |
Diapedesis | (Emigration) process by which leukocytes squeeze through adjacent cells in a blood vessel wall to enter tissue |
Embolus | Thrombus that has broken free from the blood vessel wall and entered the circulation |
Emigration | (Diapedesis) process by which leukocytes squeeze through adjacent cells in a blood vessel wall to enter tissue |
Eosinophil | WBC; 1-4% in blood ; Has Granules(deep red); Destroy invaders(antibody-coated parasites) |
Erythrocyte | RBC; transports oxygen and carbon dioxide; composed mostly of hemoglobin; mature myeloid blood cells |
Erythroproietin(EPO) | Glycoprotein that triggers the bone marrow to produce RBCs; secreted by the kidney in response to low oxygen levels |
Extrinsic Pathway | Initial coagulation pathway that begins with tissue damage and results in the activation of common pathway |
Ferritin | Protein-containing storage form of iron found in the bone marrow, liver, and spleen |
Fibrin | Insoluble, filamentous protein that forms the structure of a blood clot |
Fibrinogen | Plasma protein; 7%, produced in the liver and involved in blood clotting |
Fibrinolysis | Gradual degradation of a blood clot |
Formed Elements | Cellular components of blood; that is erythrocytes, leukocytes, and platelets |
Globin | Heme-containing globular protein that is constituent of hemoglobin |
Globulins | Plasma Protein; 30%, protein that binds to lipids and fat solute vitamins |
Granular Leukocytes | Leukocytes w/ abundant granules in their cytoplasm EX: neutrophils, eosinophils, and basophils |
Hematocrit | Volume percentage of erythrocytes in a sample of centrifuged blood |
Heme | Red, iron-containing pigment to which oxygen binds in hemoglobin |
Hemecytoblast | Hemopietic stem cell that gives rise to the formed elements of blood |
Hemoglobin | Oxygen in blood that gives it is red color |
Hemolysis | Destruction(lysis) of erythrocytes and the release of their hemoglobin into circulation |
Hemolytic Disease of the Newborn(HDN) | (Erythroblastosis Fetalis) disorder causing agglutination and hemolysis in an Rh+ fetus or newborn of an Rh- mother |
Hemophilia | Genetic disorder characterized by inadequate synthesis of clotting factors |
Hemopoiesis | Production of the formed elements of blood |
Hemopoietic Growth Factors | Chemical signals including erythropoietin, thrombopoietin, colony-stimulating factors and interleukins that regulate the differentiation and proliferation of particular blood progenitor cells |
Hemopoietic Stem Cell | Type of pluripotent stem cell that gives rise to the formed elements of blood(hemocytoblasts) |
Hemorrhage | Excessive bleeding |
Hemosiderin | Protein-containing storage form of iron found in the bone marrow, liver, and spleen |
Hemostasis | Physiological process by which bleeding ceases |
Heparin | Short-Acting anticoagulant stored in mast cells and released when issues are injured, opposes prothrombin |
Hypoxemia | Below- normal level of oxygen saturation of blood (typically<95%) |
Interleukins | Signaling molecules that may function in hemopoiesis, inflammation, and specific immune response |
Intrinsic Pathway | Initial coagulation pathway that begins w/ vascular damage or contact w/ foreign substances, and results in the activation of the common path |
Leukemia | Cancer involving leukocytes |
Leukocyte | WBCs |
Leukocytosis | Excessive leukocyte proliferation |
Leukopenia | Below-Normal production of leukocytes |
Lymphocytes | WBC; 20-35% in blood; no granules; specific responses to invaders including antibody production |
Lymphoid Stem Cell | Type of hemopoietic stem cells that gives rise to lymphocytesm including various T cells, B Cells, and NK cells, all of which function in immunity |
Lymphoma | Form of cancer in which masses of malignant T and/or B lymphocytes collect in lymph nodes, the spleen, the liver, and other tissues |
Lysozyme | Digestive enzymes w/ bacterial properties |
Macrophage | Phagocytic cell of the myeloid lineage; a mature monocyte |
Megakaryocyte | Bone marrow cell that produces platelets |
Memory Cell | Type of B or T lymphocyte that forms after exposure to a pathogen |
Monocyte | 3-8% in blood; WBC; no granules; ingest and destroy invaders and antigen presentation |
Myeloid Stem Cells | RBCs and WBCs |
Natural Killer (NK) Cells | Cytotoxic lymphocytes capable of recognizing cells that do not express "self" proteins on their plasma membrane or that contain foreign or abnormal markers; provides generalized, nonspecific immunity |
Neutrophils | WBC; 50-70% in blood ; has granules(fine; light pink to light purple) ; ingest and destroy invaders |