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Muscle Cell


Muscle Cell is at rest, the SR are pumping calcium ions into sacs Step 1
The motor neuron signals the release of acetylcholine (ACH) into the neuromuscular junction (synaptic cleft) Step 2
ACh stimulates the receptors on the sarcolemma and initiates the electrical impulse Step 3
The nerve impulse travels along the sarcolemma and down the T-tubules Step 4
The impulse triggers the release of calcium into the sarcoplasm Step 5
Calcium binds to troponin (which is the protein that holds the protein tropmyosin in place over activ=ns binding site) Step 6
Tropomyosin shifts exposing the active site on actin Step 7
The head of myosin (energized by ATP) binds to actin (cross-bridge) abd pulls the thin filament (attach to Zplates of sacromere) past them (power stroke) Step 8
In the presence of ATP, each myosin head releases actin and then binds to the next active site (muscle fiber shorten/contract as think and thin filaments slide past eachother) Step 9
The sarcoplasmic reticulum starts actively pumping calcium ions back into the storage sacs. Step 10
As calcium is removed from troponin, this allows tropomyosin to again block the active sites on actin and the muscle relaxes Step 11
Created by: bfergie