click below
click below
Normal Size Small Size show me how
Pharmacology
Psychiatric Pharmacology Flashcards
Question | Answer |
---|---|
What are the indications and contraindications for Lithium? | Indications: prophylaxis and treatment of mania, prophylaxis of bipolar affective disorder, treatment-resistant depression Contraindications: dehydration, untreated hypothyroidism |
What is the mechanism of action of Lithium? | Widely distributed within the CNS and interacts with receptors to decrease noradrenaline release and increase serotonin synthesis |
What are the side effects of Lithium? | Fine tremor, renal impairment, thirst, weight gain Toxicity Long-term treatment can cause thyroid disorders and mild cognitive impairment |
What are the signs of toxicity of Lithium? | Toxicity signs usually appear at levels above 1.3mmol/l o Early signs: tremor, nausea and vomiting, metallic taste in mouth o Late signs: disorientation, dysarthria (slurred speech), convulsions, coma o Death from cardiac or pulmonary complications |