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Psychiatric Pharmacology Flashcards

What are the indications and contraindications for Lithium? Indications: prophylaxis and treatment of mania, prophylaxis of bipolar affective disorder, treatment-resistant depression Contraindications: dehydration, untreated hypothyroidism
What is the mechanism of action of Lithium? Widely distributed within the CNS and interacts with receptors to decrease noradrenaline release and increase serotonin synthesis
What are the side effects of Lithium? Fine tremor, renal impairment, thirst, weight gain Toxicity Long-term treatment can cause thyroid disorders and mild cognitive impairment
What are the signs of toxicity of Lithium? Toxicity signs usually appear at levels above 1.3mmol/l o Early signs: tremor, nausea and vomiting, metallic taste in mouth o Late signs: disorientation, dysarthria (slurred speech), convulsions, coma o Death from cardiac or pulmonary complications
Created by: josie3