Busy. Please wait.

show password
Forgot Password?

Don't have an account?  Sign up 

Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
Don't know
remaining cards
To flip the current card, click it or press the Spacebar key.  To move the current card to one of the three colored boxes, click on the box.  You may also press the UP ARROW key to move the card to the "Know" box, the DOWN ARROW key to move the card to the "Don't know" box, or the RIGHT ARROW key to move the card to the Remaining box.  You may also click on the card displayed in any of the three boxes to bring that card back to the center.

Pass complete!

"Know" box contains:
Time elapsed:
restart all cards
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

BBC pharm

CH 37: hyperlipidemia drugs

any disorder marked by excess erum lipids hyperlipidemia
two types of hyperlipidemias hypertriglyceridemia and hypercholesterolemia
typically defined as serum triglycerid elevel in excess of 150 mg/dL general trmt geared toward diet modification. meds used only if unsuccessful. fibric acid agnets are the drugs of choice hypertriglyceridemia
the CV risk factors for cholesterol management? smoking, hypertension, fam history of CAD, age, high LDL, low HDL, smoking, hypertension, fam history
persons at high risk? those patients with heart disease or any of its equivalents. this includes all patients with a history of stable angina, unstable angina, MI, mesenteric ischemia, AAA, peripheral vascular disaease, atherosclerosis mediated cerebrovascular accident, DM.
also known as nicotinici acid. it decreaess hepatic uptake of released free atty acids. inhibits lipolysis in fat cells, and, therefore, decreases free fatty acid levels. ultimate effects include increasing HDL and decreasing LDL. niacin
this is a type of fibric acid agent, is not used often du eto its significant side effects. works to increase lipoprotein lipase activity, thus decreasing chylomicron and VLDL levels by increasing tissue uptake of hte triglycerides. clofibrate
this is a bile acid sequestrant, binds cholesterol in the gut. therefore, there is increaed hepatic cholesterol synthesis. this increases hepatic serum LDL uptake. overall, plasma LDL is decreased bu 30%, VLDLs are increased by 20%,. cholestyramine. colestipol and colesevelam fall into this class.
this is a representative HMG CoA reductase inhibitor (statin). others include simvastatin, rosuvastatin lovastatin
AE of all HMG CoA reductase inhibitors? hepatotoxic.
MOA of HMC CoA reductase inhibitors? decrease the initial rate limiting step of cholesterol synthesis, especially in hepatocytes. therefore, this decreases the pool of intracellular cholesterol, increasing the need for exogenous cholesterol.
this upregulates ACE production. staatins, through their inhibition of HMGCoA reductase and its pathways, cause a reduction in mevalonate levels mevalonate
Created by: aferdo01